C
Christian Wohn
Researcher at Aix-Marseille University
Publications - 9
Citations - 726
Christian Wohn is an academic researcher from Aix-Marseille University. The author has contributed to research in topics: Psoriasis & Antigen. The author has an hindex of 8, co-authored 9 publications receiving 594 citations. Previous affiliations of Christian Wohn include French Institute of Health and Medical Research & Erasmus University Rotterdam.
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Journal ArticleDOI
IL-1F5, -F6, -F8, and -F9: A Novel IL-1 Family Signaling System That Is Active in Psoriasis and Promotes Keratinocyte Antimicrobial Peptide Expression
Andrew Johnston,Xianying Xing,Andrew M. Guzman,Mary Beth Riblett,Candace M. Loyd,Nicole L. Ward,Christian Wohn,Errol P. Prens,Frank Wang,Lisa E. Maier,Sewon Kang,John J. Voorhees,James T. Elder,James T. Elder,Johann E. Gudjonsson +14 more
TL;DR: Important roles for these novel cytokines in inflammatory skin diseases are suggested and these peptides are identified as potential targets for antipsoriatic therapies.
Journal ArticleDOI
Genome-wide expression profiling of five mouse models identifies similarities and differences with human psoriasis.
William R. Swindell,Andrew Johnston,Steve Carbajal,Gangwen Han,Christian Wohn,Jun Lu,Xianying Xing,Rajan P. Nair,John J. Voorhees,James T. Elder,James T. Elder,Xiao Jing Wang,Shigetoshi Sano,Errol P. Prens,John DiGiovanni,Mark R. Pittelkow,Nicole L. Ward,Johann E. Gudjonsson +17 more
TL;DR: The approach used in this paper provides an objective and quantitative method for evaluation of proposed mouse models of psoriasis, which can be strategically applied in future studies to score strengths of mouse phenotypes relative to specific aspects of human Psoriasis.
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Dynamics and Transcriptomics of Skin Dendritic Cells and Macrophages in an Imiquimod-Induced, Biphasic Mouse Model of Psoriasis.
Dorothea Terhorst,Rabie Chelbi,Christian Wohn,Camille Malosse,Samira Tamoutounour,Audrey Jorquera,Marc Bajénoff,Marc Dalod,Bernard Malissen,Sandrine Henri +9 more
TL;DR: Genetic depletion of LCs permitted to evaluate their function during both phases of the biphasic psoriasis-like model and demonstrated that their absence resulted in a late phase that is associated with enhanced neutrophil infiltration, which supports an anti-inflammatory role of Langerhans cells during the course of psorasis-like inflammation.
Journal ArticleDOI
Antagonization of IL-17A Attenuates Skin Inflammation and Vascular Dysfunction in Mouse Models of Psoriasis
Rebecca Schüler,Anna Brand,Sabrina Klebow,Johannes Wild,Flávio P. Veras,Elisabeth Ullmann,Siyer Roohani,Frank Kolbinger,Sabine Kossmann,Christian Wohn,Andreas Daiber,Thomas Münzel,Philip Wenzel,Ari Waisman,Björn E. Clausen,Susanne Karbach +15 more
TL;DR: Successful anti-IL-17A treatment of psoriatic skin lesions diminished peripheral oxidative stress levels, proinflammatory cytokines, and vascular inflammation, highlighting the pivotal role of IL- 17A linking the development of skin lesions and vascular disease in psoriasis.
Journal ArticleDOI
A Subset of Type I Conventional Dendritic Cells Controls Cutaneous Bacterial Infections through VEGFα-Mediated Recruitment of Neutrophils
Baptiste Janela,Amit Patel,Mai Chan Lau,Chi Ching Goh,Rasha Msallam,Wan Ting Kong,Michael G. Fehlings,Sandra Hubert,Josephine Lum,Yannick Simoni,Benoit Malleret,Benoit Malleret,Francesca Zolezzi,Francesca Zolezzi,Jinmiao Chen,Michael Poidinger,Ansuman T. Satpathy,Carlos G. Briseño,Christian Wohn,Bernard Malissen,Kenneth M. Murphy,Alexander A. Maini,Leen Vanhoutte,Martin Guilliams,Emmanuel Vial,Laurent F. Hennequin,Evan W. Newell,Lai Guan Ng,Philippe Musette,Simon Yona,Feriel Hacini-Rachinel,Florent Ginhoux +31 more
TL;DR: Skin cDC1s are essential regulators of the innate response in cutaneous immunity and have roles beyond classical antigen presentation as well as in a model of bacterial insult in human skin.