A Subset of Type I Conventional Dendritic Cells Controls Cutaneous Bacterial Infections through VEGFα-Mediated Recruitment of Neutrophils
Baptiste Janela,Amit Patel,Mai Chan Lau,Chi Ching Goh,Rasha Msallam,Wan Ting Kong,Michael G. Fehlings,Sandra Hubert,Josephine Lum,Yannick Simoni,Benoit Malleret,Benoit Malleret,Francesca Zolezzi,Francesca Zolezzi,Jinmiao Chen,Michael Poidinger,Ansuman T. Satpathy,Carlos G. Briseño,Christian Wohn,Bernard Malissen,Kenneth M. Murphy,Alexander A. Maini,Leen Vanhoutte,Martin Guilliams,Emmanuel Vial,Laurent F. Hennequin,Evan W. Newell,Lai Guan Ng,Philippe Musette,Simon Yona,Feriel Hacini-Rachinel,Florent Ginhoux +31 more
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TLDR
Skin cDC1s are essential regulators of the innate response in cutaneous immunity and have roles beyond classical antigen presentation as well as in a model of bacterial insult in human skin.About:
This article is published in Immunity.The article was published on 2019-04-16 and is currently open access. It has received 42 citations till now. The article focuses on the topics: Immune system & Dendritic cell.read more
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Journal ArticleDOI
Development of a vaccine against Staphylococcus aureus invasive infections: Evidence based on human immunity, genetics and bacterial evasion mechanisms.
Lloyd S. Miller,Vance G. Fowler,Sanjay K. Shukla,Sanjay K. Shukla,Warren E. Rose,Richard A. Proctor +5 more
TL;DR: The evidence presented form the basis for a hypothesis that staphylococcal toxins are important virulence factors, and targeting the neutralization of these toxins are more likely to provide a therapeutic benefit in contrast to prior vaccine attempts to generate antibodies to facilitate opsonophagocytosis.
Book ChapterDOI
Dendritic cell subsets and locations.
TL;DR: Dendritic cells are a unique class of immune cells that act as a bridge between innate and adaptive immunity, and are classified into different subsets based on an integrated approach considering their surface phenotype, expression of unique and conserved molecules, ontogeny, and functions.
Journal ArticleDOI
Genetic models of human and mouse dendritic cell development and function.
David A. Anderson,Charles-Antoine Dutertre,Florent Ginhoux,Florent Ginhoux,Florent Ginhoux,Kenneth M. Murphy +5 more
TL;DR: Genetic models of dendritic cell (DC) development in mice have aided the understanding of the redundant and non-redundant functions of DC subsets and enabled translation of these findings to human DCs.
Journal ArticleDOI
Efficacy and tolerability of bevacizumab in patients with severe Covid-19.
Jiaojiao Pang,Feng Xu,Feng Xu,Gianmarco Aondio,Yu Li,Alberto Fumagalli,Ming Lu,Giuseppe Valmadre,Jie Wei,Yuan Bian,Margherita Canesi,Giovanni Damiani,Yuan Zhang,Dexin Yu,Jun Chen,Xiang Ji,Wenhai Sui,Bailu Wang,Shuo Wu,Attila Kovacs,Miriam Revera,Hao Wang,Xu Jing,Ying Zhang,Yuguo Chen,Yuguo Chen,Yihai Cao +26 more
TL;DR: In this paper, the anti-vascular endothelial growth factor (VEGF) drug bevacizumab was used for treating Covid-19 patients with lung pathological and vascular changes.
Journal ArticleDOI
Monocytes, macrophages, dendritic cells and neutrophils: an update on lifespan kinetics in health and disease
TL;DR: In this paper, the kinetic profiles of innate myeloid cells during steady state and pathology are analyzed to support the rational development of therapies to boost the production of these cells in times of need or reduce them when detrimental.
References
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Full-length RNA-seq from single cells using Smart-seq2
Simone Picelli,Omid R. Faridani,Åsa K. Björklund,Gösta Winberg,Sven Sagasser,Rickard Sandberg +5 more
TL;DR: In this article, the authors presented a detailed protocol for Smart-seq2 that allows the generation of full-length cDNA and sequencing libraries by using standard reagents, and the entire protocol takes ∼2 d from cell picking to having a final library ready for sequencing; sequencing will require an additional 1-3 d depending on the strategy and sequencer.
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CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis
Bin-Zhi Qian,Jiufeng Li,Hui Zhang,Takanori Kitamura,Jinghang Zhang,Liam Campion,Elizabeth Kaiser,Linda A. Snyder,Jeffrey W. Pollard +8 more
TL;DR: The mechanistic link between CCL2 expression and macrophage infiltration are correlated with poor prognosis and metastatic disease in human breast cancer and the origin of these macrophages is defined by showing that Gr1-positive inflammatory monocytes are preferentially recruited to pulmonary metastases but not to primary mammary tumours in mice.
Full-length RNA-seq from single cells using
TL;DR: A detailed protocol is presented for Smart-seq2 that allows the generation of full-length cDNA and sequencing libraries by using standard reagents and the lack of strand specificity and the inability to detect nonpolyadenylated (polyA−) RNA.
Journal ArticleDOI
Batf3 Deficiency Reveals a Critical Role for CD8α+ Dendritic Cells in Cytotoxic T Cell Immunity
Kai Hildner,Brian T. Edelson,Whitney E. Purtha,Mark S Diamond,Hirokazu Matsushita,Masako Kohyama,Boris Calderon,Barbara U. Schraml,Emil R. Unanue,Michael S. Diamond,Robert D. Schreiber,Theresa L. Murphy,Kenneth M. Murphy +12 more
TL;DR: An important role is suggested for CD8α+ dendritic cells and cross-presentation in responses to viruses and in tumor rejection in Batf3–/– mice.
Journal ArticleDOI
Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation
Yanming Wang,Ming‐ming Li,Sonja C. Stadler,Sonja C. Stadler,Sarah Correll,Pingxin Li,Danchen Wang,Ryo Hayama,Lauriebeth Leonelli,Hyunsil Han,Sergei A. Grigoryev,C. David Allis,Scott A. Coonrod +12 more
TL;DR: It is shown that the hypercitrullination of histones by PAD4 mediates chromatin decondensation in granulocytes/neutrophils, and citrullinations of biochemically defined avian nucleosome arrays inhibits their compaction by the linker histone H5 to form higher order chromatin structures.
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