Lee Murphy

TL;DR: Site-specific DNA methylation changes in IBD relate to underlying genotype and associate with cell-specific alteration in gene expression, andSeparated cell data shows that IBD-associated hypermethylation within the TXK promoter region negatively correlates with gene expression in whole-blood and CD8+ T cells, but not other cell types.

TL;DR: It is shown that a large number of CpGs across the genome, as a result of environmental and/or genetic constraints, have stable DNAm variation over the human lifetime, despite some sites being highly modifiable by the environment.

TL;DR: The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms as mentioned in this paper .

TL;DR: Gene order evolution in two eukaryotes was studied by comparing the Saccharomyces cerevisiae genome sequence to extensive new data from whole-genome shotgun and cosmid sequencing of Candida albicans to estimate that about 1,100 single-gene inversions have occurred since the divergence between these species.

TL;DR: The genetic heritability of a number of complex traits and diseases was partitioned into components due to mQTL and the remainder of the genome and enrichment was observed for height and coronary artery disease.