L
Line S. Reinert
Researcher at Aarhus University
Publications - 45
Citations - 2705
Line S. Reinert is an academic researcher from Aarhus University. The author has contributed to research in topics: Innate immune system & Immune system. The author has an hindex of 20, co-authored 40 publications receiving 1856 citations. Previous affiliations of Line S. Reinert include University of Maryland Marlene and Stewart Greenebaum Cancer Center & Aarhus University Hospital.
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Journal ArticleDOI
Attenuation of cGAS-STING Signaling Is Mediated by a p62/SQSTM1-dependent Autophagy Pathway Activated by TBK1
Thaneas Prabakaran,Chiranjeevi Bodda,Chiranjeevi Bodda,Christian Krapp,Bao-Cun Zhang,Maria H Christensen,Chenglong Sun,Line S. Reinert,Yujia Cai,Søren B. Jensen,Morten K Skouboe,Jens R. Nyengaard,Craig B. Thompson,Robert Jan Lebbink,Ganes C. Sen,Geert van Loo,Rikke Nielsen,Masaaki Komatsu,Lene N. Nejsum,Martin R. Jakobsen,Mads Gyrd-Hansen,Søren R. Paludan +21 more
TL;DR: It is reported that STING degradation following activation of the pathway occurs through autophagy and is mediated by p62/SQSTM1, which is phosphorylated by TBK1 to direct ubiquitinated STING to autophagosomes.
Journal ArticleDOI
SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate
David Olagnier,Ensieh Farahani,Jacob Thyrsted,Julia Blay-Cadanet,Angela Herengt,Manja Idorn,Alon Schneider Hait,Alon Schneider Hait,Bruno Hernáez,Alice Knudsen,Marie B. Iversen,Mirjam Schilling,Sofie E. Jørgensen,Sofie E. Jørgensen,Michelle M. Thomsen,Michelle M. Thomsen,Line S. Reinert,Michael Lappe,Huy-Dung Hoang,Victoria H. Gilchrist,Anne Louise Hansen,Rasmus Ottosen,Camilla G. Nielsen,Charlotte Möller,Demi van der Horst,Suraj Peri,Siddharth Balachandran,Jinrong Huang,Martin R. Jakobsen,Esben B. Svenningsen,Thomas B. Poulsen,Lydia Bartsch,Anne L. Thielke,Yonglun Luo,Tommy Alain,Jan Rehwinkel,Antonio Alcami,John Hiscott,Trine H. Mogensen,Trine H. Mogensen,Søren R. Paludan,Christian K. Holm +41 more
TL;DR: NRF2 agonists 4-OI and DMF induce a distinct IFN-independent antiviral program that is broadly effective in limiting virus replication and in suppressing the pro-inflammatory responses of human pathogenic viruses, including SARS-CoV2.
Journal ArticleDOI
Sensing of HSV-1 by the cGAS-STING pathway in microglia orchestrates antiviral defence in the CNS
Line S. Reinert,Katarína Lopušná,Katarína Lopušná,Henriette Winther,Chenglong Sun,Martin K. Thomsen,Ramya Nandakumar,Trine H. Mogensen,Trine H. Mogensen,Morten Meyer,Christian Bjerggaard Vaegter,Jens R. Nyengaard,Katherine A. Fitzgerald,Søren R. Paludan +13 more
TL;DR: Sensing of HSV-1 infection in the CNS by microglia through the cGAS–STING pathway orchestrates an antiviral program that includes type I IFNs and immune-priming of other cell types.
Journal ArticleDOI
TLR2 and TLR9 Synergistically Control Herpes Simplex Virus Infection in the Brain
Louise N. Sørensen,Line S. Reinert,Lene Malmgaard,Christina Bartholdy,Allan Randrup Thomsen,Søren R. Paludan +5 more
TL;DR: TLR2 and TLR9 synergistically stimulate innate antiviral activities, thereby protecting against HSV infection in the brain and recruiting but not activation of NK cells was impaired in TLR2/9−/− mice.
Journal ArticleDOI
HSV-1 ICP27 targets the TBK1-activated STING signalsome to inhibit virus-induced type I IFN expression
Maria H Christensen,Søren B. Jensen,Juho J. Miettinen,Stefanie Luecke,Thaneas Prabakaran,Line S. Reinert,Thomas C. Mettenleiter,Zhijian J. Chen,David M. Knipe,Rozanne M. Sandri-Goldin,Lynn W. Enquist,Rune Hartmann,Trine H. Mogensen,Stephen A. Rice,Tuula A. Nyman,Sampsa Matikainen,Søren R. Paludan +16 more
TL;DR: It is shown that HSV‐1 inhibits expression of type I IFN in human macrophages through ICP27‐dependent targeting of the TBK1‐activated STING signalsome.