L
Lorenz Wernisch
Researcher at University of Cambridge
Publications - 79
Citations - 5165
Lorenz Wernisch is an academic researcher from University of Cambridge. The author has contributed to research in topics: Gene & Gene expression profiling. The author has an hindex of 32, co-authored 78 publications receiving 4675 citations. Previous affiliations of Lorenz Wernisch include European Bioinformatics Institute & Free University of Berlin.
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Journal ArticleDOI
Solving the riddle of codon usage preferences: a test for translational selection
TL;DR: A model where the coevolution of genome size and tRNA genes explains the observed patterns in translational selection in all living organisms is proposed, which finally unifies the understanding of codon usage across prokaryotes and eukaryotes.
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Microarray analysis after RNA amplification can detect pronounced differences in gene expression using limma
TL;DR: It is concluded that microarray analysis of amplified samples performs best at detecting differences in gene expression, when these are large and when limma statistics are used.
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New gene functions in megakaryopoiesis and platelet formation
Christian Gieger,Aparna Radhakrishnan,Ana Cvejic,Weihong Tang,Eleonora Porcu,Giorgio Pistis,Jovana Serbanovic-Canic,Ulrich Elling,Alison H. Goodall,Yann Labrune,Lorna M. Lopez,Reedik Mägi,Stuart Meacham,Yukinori Okada,Nicola Pirastu,Rossella Sorice,Alexander Teumer,Katrin Voss,Weihua Zhang,Ramiro Ramirez-Solis,Joshua C. Bis,David Ellinghaus,Martin Gögele,Jouke-Jan Hottenga,Claudia Langenberg,Peter Kovacs,Paul F. O'Reilly,So Youn Shin,Tõnu Esko,Jaana Hartiala,Stavroula Kanoni,Federico Murgia,Afshin Parsa,Jonathan Stephens,Pim van der Harst,C. Ellen van der Schoot,Hooman Allayee,Antony P. Attwood,Beverley Balkau,François Bastardot,Saonli Basu,Sebastian E. Baumeister,Ginevra Biino,Lorenzo Bomba,Amélie Bonnefond,François Cambien,John C. Chambers,Francesco Cucca,Pio D'Adamo,Gail Davies,Rudolf A. de Boer,Eco J. C. de Geus,Angela Döring,Paul Elliott,Jeanette Erdmann,David M. Evans,Mario Falchi,Wei Feng,Aaron R. Folsom,Ian H. Frazer,Quince Gibson,Nicole L. Glazer,Christopher J Hammond,Anna-Liisa Hartikainen,Susan R. Heckbert,Christian Hengstenberg,Micha Hersch,Thomas Illig,Ruth J. F. Loos,Jennifer Jolley,Kay-Tee Khaw,Brigitte Kühnel,Marie-Christine Kyrtsonis,Vasiliki Lagou,Heather Lloyd-Jones,Thomas Lumley,Massimo Mangino,Andrea Maschio,Irene Mateo Leach,Barbara McKnight,Yasin Memari,Braxton D. Mitchell,Grant W. Montgomery,Yusuke Nakamura,Matthias Nauck,Gerjan Navis,Ute Nöthlings,Ilja M. Nolte,David J. Porteous,Anneli Pouta,Peter P. Pramstaller,Janne Pullat,Susan M. Ring,Jerome I. Rotter,Daniela Ruggiero,Aimo Ruokonen,Cinzia Sala,Nilesh J. Samani,Jennifer G. Sambrook,David Schlessinger,Stefan Schreiber,Heribert Schunkert,James Scott,Nicholas L. Smith,Harold Snieder,John M. Starr,Michael Stumvoll,Atsushi Takahashi,W.H. Wilson Tang,Kent D. Taylor,Albert Tenesa,Swee Lay Thein,Anke Tönjes,Manuela Uda,Sheila Ulivi,Dirk J. van Veldhuisen,Peter M. Visscher,Uwe Völker,H.-Erich Wichmann,Kerri L. Wiggins,Gonneke Willemsen,Tsun-Po Yang,Jing Hua Zhao,Paavo Zitting,John Bradley,George Dedoussis,Paolo Gasparini,Stanley L. Hazen,Andres Metspalu,Mario Pirastu,Alan R. Shuldiner,L. Joost van Pelt,Jaap Jan Zwaginga,Dorret I. Boomsma,Ian J. Deary,Andre Franke,Philippe Froguel,Santhi K. Ganesh,Marjo-Riitta Järvelin,Nicholas G. Martin,Christa Meisinger,Bruce M. Psaty,Tim D. Spector,Nicholas J. Wareham,Jan Willem N. Akkerman,Marina Ciullo,Panos Deloukas,Andreas Greinacher,Steve Jupe,Naoyuki Kamatani,Jyoti Khadake,Jaspal S. Kooner,Josef M. Penninger,Inga Prokopenko,Derek L. Stemple,Daniela Toniolo,Lorenz Wernisch,Serena Sanna,Andrew A. Hicks,Augusto Rendon,Manuel A. R. Ferreira,Willem H. Ouwehand,Nicole Soranzo +162 more
TL;DR: A high-powered meta-analysis of genome-wide association studies (GWAS) in up to 66,867 individuals of European ancestry is carried out, identifying 68 genomic loci reliably associated with platelet count and volume mapping to established and putative novel regulators of megakaryopoiesis and platelet formation.
Journal ArticleDOI
Dissection of the heat-shock response in Mycobacterium tuberculosis using mutants and microarrays.
Graham R. Stewart,Lorenz Wernisch,Richard A. Stabler,Joseph A. Mangan,Jason Hinds,Ken Laing,Douglas B. Young,Philip D. Butcher +7 more
TL;DR: A combination of targeted mutagenesis and whole-genome expression profiling was used to characterize transcription factors responsible for control of genes encoding the major heat-shock proteins of M. tuberculosis, and a novel HspR-controlled operon encodes a member of the low-molecular-mass alpha-crystallin family.
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A HaemAtlas: Characterizing gene expression in differentiated human blood cells
Nicholas A. Watkins,Arief Gusnanto,Bernard de Bono,Subhajyoti De,Diego Miranda-Saavedra,Debbie L. Hardie,W. Angenent,Antony P. Attwood,Peter D. Ellis,Wendy N. Erber,Nicola Foad,Stephen F. Garner,Clare M. Isacke,Jennifer Jolley,Kerstin Koch,Iain C. Macaulay,Sarah L. Morley,Augusto Rendon,Kate Rice,Niall C. Taylor,Daphne C. Thijssen-Timmer,Marloes R. Tijssen,C. Ellen van der Schoot,Lorenz Wernisch,Thilo Winzer,Frank Dudbridge,Christopher D. Buckley,Cordelia Langford,Sarah A. Teichmann,Berthold Göttgens,Willem H. Ouwehand,Willem H. Ouwehand +31 more
TL;DR: In this paper, the authors compared gene expression profiles of human erythroblasts, megakaryocytes, B cells, cytotoxic and helper T cells, natural killer cells, granulocytes, and monocytes using whole genome microarrays.