M
Megan K. Herbert
Researcher at Radboud University Nijmegen
Publications - 27
Citations - 1353
Megan K. Herbert is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Myositis & Inclusion body myositis. The author has an hindex of 15, co-authored 27 publications receiving 951 citations. Previous affiliations of Megan K. Herbert include Radboud University Nijmegen Medical Centre & University of Gothenburg.
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Journal ArticleDOI
Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology: A Systematic Review and Meta-analysis
Claire Bridel,van Wieringen Wn,Henrik Zetterberg,Betty M. Tijms,Charlotte E. Teunissen,José C. Álvarez-Cermeño,Ulf Andreasson,Markus Axelsson,David Bäckström,Ales Bartos,Maria Bjerke,Kaj Blennow,Kaj Blennow,A. Boxer,Lena Brundin,Joachim Burman,Tove Christensen,Lenka Fialová,Lars Forsgren,Jette L. Frederiksen,Magnus Gisslén,Elizabeth Gray,Martin Gunnarsson,Sara Hall,Oskar Hansson,Megan K. Herbert,Joel Jakobsson,Jessen-Krut J,Shorena Janelidze,Gudmundur Johannsson,Gudmundur Johannsson,Michael Jonsson,Ludwig Kappos,Mohsen Khademi,Mohsen Khademi,Michael Khalil,Jens Kuhle,Mikael Landén,Leinonen,Giancarlo Logroscino,Lu Ch,Jan Lycke,Nadia K. Magdalinou,Andrea Malaspina,Niklas Mattsson,Lieke H.H. Meeter,Mehta,Signe Modvig,Tomas Olsson,Tomas Olsson,Ross W. Paterson,Pérez-Santiago J,Fredrik Piehl,Fredrik Piehl,Pijnenburg Yal,Pyykkö Ot,Ragnarsson O,Julio C. Rojas,Romme Christensen J,Sandberg L,Carole Scherling,Jonathan M. Schott,Finn Sellebjerg,Isabella Laura Simone,Tobias Skillbäck,Stilund M,Peter Sundström,Anders Svenningsson,Rosanna Tortelli,Carla Tortorella,Alessandro Trentini,Troiano M,Martin R Turner,van Swieten Jc,Mattias Vågberg,Marcel M. Verbeek,Luisa M. Villar,Pieter Jelle Visser,Pieter Jelle Visser,Anders Wallin,Weiss A,Carsten Wikkelsö,Edward J. Wild +82 more
TL;DR: The cNfL increased with age in HC and a majority of neurological conditions, although the association was strongest in HC, and has potential to assist the differentiation of FTD from AD and PD from atypical parkinsonian syndromes.
Journal ArticleDOI
Disease specificity of autoantibodies to cytosolic 5′-nucleotidase 1A in sporadic inclusion body myositis versus known autoimmune diseases
Megan K. Herbert,Judith Stammen-Vogelzangs,Marcel M. Verbeek,Anke Rietveld,Ingrid E. Lundberg,Hector Chinoy,Janine A. Lamb,Robert G. Cooper,Mark Roberts,Umesh A. Badrising,Jan De Bleecker,Pedro Machado,Michael G. Hanna,L. Pleštilová,Jiri Vencovsky,Baziel G.M. van Engelen,Ger J. M. Pruijn +16 more
TL;DR: Heterogeneity in reactivity with the three immunodominant epitopes indicates that serological assays should not be limited to a distinct epitope region, and the need to further investigate whether distinct IBM-specific epitopes exist is investigated.
Journal ArticleDOI
Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells
Shingo Kozono,Yu-Min Lin,Hyuk-Soo Seo,Benika J. Pinch,Xiaolan Lian,Chenxi Qiu,Chenxi Qiu,Megan K. Herbert,Chun-Hau Chen,Li Tan,Ziang Jeff Gao,Walter Massefski,Zainab M. Doctor,Brian P. Jackson,Yuanzhong Chen,Sirano Dhe-Paganon,Kun Ping Lu,Xiao Zhen Zhou,Xiao Zhen Zhou +18 more
TL;DR: It is shown that this combination has potent anticancer activity in triple negative breast cancer by cooperatively targeting Pin1, a master regulator of oncogenic signaling networks, to eliminate cancer stem cells.
Journal ArticleDOI
Cis P-tau is induced in clinical and preclinical brain injury and contributes to post-injury sequelae
Onder Albayram,Asami Kondo,Rebekah Mannix,Colin Smith,Cheng-Yu Tsai,Chenyu Li,Megan K. Herbert,Jianhua Qiu,Michael C. Monuteaux,Jane A. Driver,Jane A. Driver,Sandra C. Yan,William B. Gormley,Ava M. Puccio,David O. Okonkwo,Brandon Lucke-Wold,Julian E. Bailes,William P. Meehan,Mark L. Zeidel,Kun Ping Lu,Xiao Zhen Zhou +20 more
TL;DR: It is found that in human samples obtained post TBI due to a variety of causes, cis P-tau is induced in cortical axons and cerebrospinal fluid and positively correlates with axonal injury and clinical outcome.
Journal ArticleDOI
Cytosolic 5'-nucleotidase 1A autoantibody profile and clinical characteristics in inclusion body myositis
James B. Lilleker,James B. Lilleker,Anke Rietveld,Stephen R Pye,Kuberaka Mariampillai,Olivier Benveniste,M T J Peeters,James Miller,Michael G. Hanna,Pedro Machado,M. Parton,Karina Roxana Gheorghe,Umesh A. Badrising,Ingrid E. Lundberg,Sabrina Sacconi,Megan K. Herbert,Neil McHugh,Bryan Lecky,C Brierley,David Hilton-Jones,Janine A. Lamb,Mark E. Roberts,Robert G. Cooper,Robert G. Cooper,Robert G. Cooper,Christiaan G J Saris,Ger J. M. Pruijn,Hector Chinoy,Hector Chinoy,Hector Chinoy,B.G.M. van Engelen +30 more
TL;DR: Differences were observed in clinical and histopathological features between anticytosolic 5′-nucleotidase 1A antibody positive and negative patients with inclusion body myositis, and antibody-positive patients had a higher adjusted mortality risk.