M
Maria G. Gomez-Lorenzo
Researcher at GlaxoSmithKline
Publications - 23
Citations - 1146
Maria G. Gomez-Lorenzo is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: Plasmodium falciparum & Drug resistance. The author has an hindex of 10, co-authored 19 publications receiving 972 citations. Previous affiliations of Maria G. Gomez-Lorenzo include Wadsworth Center & University at Albany, SUNY.
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Journal ArticleDOI
Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation
Christian M. T. Spahn,Christian M. T. Spahn,Christian M. T. Spahn,Maria G. Gomez-Lorenzo,Maria G. Gomez-Lorenzo,Robert A. Grassucci,Robert A. Grassucci,René Jørgensen,Gregers R. Andersen,Roland Beckmann,Pawel A. Penczek,Juan P. G. Ballesta,Joachim Frank,Joachim Frank,Joachim Frank +14 more
TL;DR: An 11.7‐Å‐resolution cryo‐EM map of the yeast 80S·eEF2 complex in the presence of the antibiotic sordarin was interpreted in molecular terms, revealing large conformational changes within eEF2 and the 80S ribosome, including a rearrangement of the functionally important ribosomal intersubunit bridges.
Journal ArticleDOI
Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics
Annie N. Cowell,Eva S. Istvan,Amanda K. Lukens,Amanda K. Lukens,Maria G. Gomez-Lorenzo,Manu Vanaerschot,Tomoyo Sakata-Kato,Erika L. Flannery,Pamela Magistrado,Edward Owen,Matthew Abraham,Gregory LaMonte,Heather J. Painter,Roy Williams,Virginia Franco,María Linares,Ignacio Arriaga,Selina Bopp,Victoria C. Corey,Nina F. Gnädig,Olivia Coburn-Flynn,Christin Reimer,Purva Gupta,James M. Murithi,Pedro A. Moura,Olivia Fuchs,Erika Sasaki,Sang W. Kim,Christine H. Teng,Lawrence T. Wang,Aslı Akidil,Sophie H. Adjalley,Paul Willis,Dionicio Siegel,Olga Tanaseichuk,Yang Zhong,Yingyao Zhou,Manuel Llinás,Sabine Ottilie,Francisco-Javier Gamo,Marcus C. S. Lee,Marcus C. S. Lee,Daniel E. Goldberg,David A. Fidock,Dyann F. Wirth,Dyann F. Wirth,Elizabeth A. Winzeler,Elizabeth A. Winzeler +47 more
TL;DR: Genome sequencing elucidates potential drug resistance in the malaria parasite and identifies antimalarial targets and drug-resistance genes, as well as discovering hitherto unrecognized drug target–inhibitor pairs.
Journal ArticleDOI
Three-dimensional cryo-electron microscopy localization of EF2 in the Saccharomyces cerevisiae 80S ribosome at 17.5 A resolution.
Maria G. Gomez-Lorenzo,Christian M. T. Spahn,Rajendra K. Agrawal,Robert A. Grassucci,Pawel A. Penczek,Kalpana Chakraburtty,Juan P. G. Ballesta,Jose Luis Lavandera,Jose F. Garcia-Bustos,Joachim Frank +9 more
TL;DR: The shape and position of domain IV of EF2 suggest that it might interact directly with P‐site‐bound tRNA, and the overall arrangement of the complex from Saccharomyces cerevisiae corresponds to that previously seen in Escherichia coli.
Journal ArticleDOI
A broad analysis of resistance development in the malaria parasite
Victoria C. Corey,Amanda K. Lukens,Amanda K. Lukens,Eva S. Istvan,Marcus C. S. Lee,Virginia Franco,Pamela Magistrado,Olivia Coburn-Flynn,Tomoyo Sakata-Kato,Olivia Fuchs,Nina F. Gnädig,Greg Goldgof,María Linares,Maria G. Gomez-Lorenzo,Cristina de Cozar,Maria Jose Lafuente-Monasterio,Sara Prats,Stephan Meister,Olga Tanaseichuk,Melanie Wree,Yingyao Zhou,Paul Willis,Francisco-Javier Gamo,Daniel E. Goldberg,David A. Fidock,Dyann F. Wirth,Dyann F. Wirth,Elizabeth A. Winzeler +27 more
TL;DR: The data indicate that pre-existing resistance may not be a major hurdle for novel-target antimalarial candidates, and focusing on fast-killing compounds may result in a slower onset of clinical resistance.
Journal ArticleDOI
Large T antigen on the simian virus 40 origin of replication: a 3D snapshot prior to DNA replication.
Maria G. Gomez-Lorenzo,Mikel Valle,Mikel Valle,Joachim Frank,Joachim Frank,Claudia Gruss,Carlos Oscar S. Sorzano,Xiaojiang S. Chen,Luis Enrique Donate,José María Carazo +9 more
TL;DR: The structure of the T antigen at the origin of replication can be understood as a snapshot of the dynamic events leading to DNA unwinding and a model for the initiation of simian virus 40 DNA replication is proposed.