M
Mark E. Fortini
Researcher at Thomas Jefferson University
Publications - 50
Citations - 6208
Mark E. Fortini is an academic researcher from Thomas Jefferson University. The author has contributed to research in topics: Notch signaling pathway & Presenilin. The author has an hindex of 27, co-authored 50 publications receiving 5983 citations. Previous affiliations of Mark E. Fortini include University of Düsseldorf & National Institutes of Health.
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Journal ArticleDOI
Comparative Genomics of the Eukaryotes
Gerald M. Rubin,Mark Yandell,Jennifer R. Wortman,George L. Gabor,Miklos,Catherine R. Nelson,Iswar K. Hariharan,Mark E. Fortini,Peter W. Li,Rolf Apweiler,Wolfgang Fleischmann,J. Michael Cherry,Steven Henikoff,Marian P. Skupski,Sima Misra,Michael Ashburner,Ewan Birney,Mark S. Boguski,Thomas Brody,Peter Brokstein,Susan E. Celniker,Stephen A. Chervitz,David Coates,Anibal Cravchik,Andrei Gabrielian,Richard F. Galle,William M. Gelbart,Reed A. George,Lawrence S.B. Goldstein,Fangcheng Gong,Ping Guan,Nomi L. Harris,Bruce A. Hay,Roger A. Hoskins,Jiayin Li,Zhenya Li,Richard O. Hynes,Steven J.M. Jones,Peter M. Kuehl,Bruno Lemaitre,J. Troy Littleton,Deborah K. Morrison,Christopher J. Mungall,Patrick H. O'Farrell,Oxana K. Pickeral,Chris Shue,Leslie B. Vosshall,Jiong Zhang,Qi Zhao,Xiangqun H. Zheng,Fei Zhong,Wenyan Zhong,Richard A. Gibbs,J. Craig Venter,Mark Raymond Adams,Suzanna E. Lewis +55 more
TL;DR: The fly has orthologs to 177 of the 289 human disease genes examined and provides the foundation for rapid analysis of some of the basic processes involved in human disease.
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Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling.
TL;DR: The Notch signalling pathway uses a relatively direct mechanism, in which the intracellular domain of the receptor is liberated by intramembrane cleavage and translocates to the nucleus as discussed by the authors.
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Notch Signaling: The Core Pathway and Its Posttranslational Regulation
TL;DR: This review describes the core developmental logic of Notch signaling and how regulatory mechanisms tailor Notch pathway outputs to specific developmental scenarios.
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Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.
TL;DR: It is shown that presenilin is required for the normal proteolytic production of carboxy-terminal Notch fragments that are needed for receptor maturation and signalling, and that genetically it acts upstream of both the membrane-bound form and the activated nuclear form of Notch.
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Endosomal entry regulates Notch receptor activation in Drosophila melanogaster
TL;DR: It is shown that endosomal access of the Notch receptor is critical to achieve physiological levels of signaling and further suggest that altered residence in distinct endocytic compartments could underlie pathologies involving aberrant Notch pathway activation.