M
Mark E. Gurney
Researcher at deCODE genetics
Publications - 147
Citations - 22658
Mark E. Gurney is an academic researcher from deCODE genetics. The author has contributed to research in topics: Amyotrophic lateral sclerosis & Motor neuron. The author has an hindex of 55, co-authored 140 publications receiving 21917 citations. Previous affiliations of Mark E. Gurney include Loyola University Medical Center & Northwestern University.
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Journal ArticleDOI
Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation.
Mark E. Gurney,Haifeng Pu,Arlene Y. Chiu,Mauro C. Dal Canto,Cynthia Y. Polchow,Denise D. Alexander,Jan Caliendo,Afif Hentati,Young W. Kwon,Han Xiang Deng,W. Chen,Ping Zhai,Robert L. Sufit,Teepu Siddique +13 more
TL;DR: In this article, the authors found that mutations of human Cu,Zn superoxide dismutase (SOD) contribute to the pathogenesis of familial amyotrophic lateral sclerosis (ALS).
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Neuregulin 1 and Susceptibility to Schizophrenia
Hreinn Stefansson,Engilbert Sigurdsson,Valgerdur Steinthorsdottir,Soley Bjornsdottir,Thordur Sigmundsson,Shyamali Ghosh,J Brynjolfsson,Steinunn Gunnarsdottir,Omar Ivarsson,Thomas T. Chou,Omar Hjaltason,Birgitta Birgisdottir,Helgi Jonsson,Vala G. Gudnadottir,Elsa Gudmundsdottir,Asgeir Björnsson,Brynjolfur Ingvarsson,Andres Ingason,Sigmundur Sigfusson,Hronn Hardardottir,Richard P. Harvey,Richard P. Harvey,Donna Lai,Mingdong Zhou,Daniela Brunner,Vincent Mutel,Acuna Gonzalo,Greg Lemke,Jesus Sainz,Gardar Johannesson,Thorkell Andresson,Daniel F. Gudbjartsson,Andrei Manolescu,Michael L. Frigge,Mark E. Gurney,Augustine Kong,Jeffrey R. Gulcher,Hannes Petursson,Kari Stefansson +38 more
TL;DR: The results of a genomewide scan of schizophrenia families in Iceland show that schizophrenia maps to chromosome 8p, and extensive fine-mapping of the 8p locus and haplotype-association analysis identifies neuregulin 1 (NRG1) as a candidate gene for schizophrenia.
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Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity.
Riqiang Yan,Michael Jerome Bienkowski,Mary E. Shuck,Huiyi Miao,Monica C. Tory,Adele M. Pauley,John R. Brashler,Nancy C. Stratman,W. Rodney Mathews,Allen E. Buhl,Donald B. Carter,Alfredo G. Tomasselli,Luis A. Parodi,Robert L. Heinrikson,Mark E. Gurney +14 more
TL;DR: Asp2 is a new protein target for drugs that are designed to block the production of amyloid β-peptide peptide and the consequent formation ofAmyloid plaque in Alzheimer's disease.
Journal ArticleDOI
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes.
Valgerdur Steinthorsdottir,Gudmar Thorleifsson,Inga Reynisdottir,Rafn Benediktsson,Thorbjorg Jonsdottir,G. Bragi Walters,Unnur Styrkarsdottir,Solveig Gretarsdottir,Valur Emilsson,Shyamali Ghosh,Adam Baker,Steinunn Snorradottir,Hjordis Bjarnason,Maggie C.Y. Ng,Torben Hansen,Yu Z. Bagger,Robert L. Wilensky,Muredach P. Reilly,Adebowale Adeyemo,Yuanxiu Chen,Jie Zhou,Vilmundur Gudnason,Guanjie Chen,Hanxia Huang,Kerrie Lashley,Ayo Doumatey,Wing-Yee So,Ronald Ching-Wa Ma,Gitte Andersen,Knut Borch-Johnsen,Knut Borch-Johnsen,Knut Borch-Johnsen,Torben Jørgensen,Jana V. van Vliet-Ostaptchouk,Marten H. Hofker,Marten H. Hofker,Cisca Wijmenga,Cisca Wijmenga,Claus Christiansen,Daniel J. Rader,Charles N. Rotimi,Mark E. Gurney,Juliana C.N. Chan,Oluf Pedersen,Oluf Pedersen,Gunnar Sigurdsson,Jeffrey R. Gulcher,Unnur Thorsteinsdottir,Augustine Kong,Kari Stefansson +49 more
TL;DR: A genome-wide association study for type 2 diabetes (T2D) in Icelandic cases and controls is conducted, and it is found that a previously described variant in the transcription factor 7-like 2 gene (TCF7L2) gene conferred the most significant risk.
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The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke
Anna Helgadottir,Andrei Manolescu,Gudmar Thorleifsson,Solveig Gretarsdottir,Helga Jonsdottir,Unnur Thorsteinsdottir,Nilesh J. Samani,Gudmundur Gudmundsson,Struan F.A. Grant,Gudmundur Thorgeirsson,Sigurlaug Sveinbjörnsdóttir,Einar M. Valdimarsson,Stefan E Matthiasson,Halldor Johannsson,Olof Gudmundsdottir,Mark E. Gurney,Jesus Sainz,Margret Thorhallsdottir,Margret B. Andresdottir,Michael L. Frigge,Eric J. Topol,Augustine Kong,Vilmundur Gudnason,Hakon Hakonarson,Jeffrey R. Gulcher,Kari Stefansson +25 more
TL;DR: It is concluded that variants of ALOX5AP are involved in the pathogenesis of both myocardial infarction and stroke by increasing leukotriene production and inflammation in the arterial wall.