M
Mark Hallett
Researcher at National Institutes of Health
Publications - 1234
Citations - 136876
Mark Hallett is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Transcranial magnetic stimulation & Motor cortex. The author has an hindex of 186, co-authored 1170 publications receiving 123741 citations. Previous affiliations of Mark Hallett include Government of the United States of America & Armed Forces Institute of Pathology.
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Journal ArticleDOI
Effects of TPH2 gene variation and childhood trauma on the clinical and circuit-level phenotype of functional movement disorders.
Primavera A. Spagnolo,Gina Norato,Carine W. Maurer,David Goldman,Colin A. Hodgkinson,Silvina G. Horovitz,Mark Hallett +6 more
TL;DR: This is the first study showing that the TPH2 genotype may modulate FMD both directly and interactively with childhood trauma, and these findings support a potential molecular mechanism modulating FMD phenotype.
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Posterior parietal negativity preceding self-paced praxis movements.
TL;DR: The posterior parietal negativity (PPN) suggests that early parietal activity is essential for tool-use movements and is not a part of preparing simple movements.
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Haplotype analysis at the DYT1 Locus in ashkenazi jewish patients with occupational hand dystonia
T. Gasser,T. Gasser,C. M. Bove,Laurie J. Ozelius,Mark Hallett,Michael E. Charness,Fred H. Hochberg,Xandra O. Breakefield +7 more
TL;DR: Findings argue against a role for the founder mutation in the DYT1 gene in the etiology of occupational hand dystonia in this ethnic group and suggest excessive, repetitive use may serve as the inciting cause of some focal dystonias.
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Sensory disinhibition on passive movement in cervical dystonia.
Mark Obermann,Clemens Vollrath,Armin de Greiff,Elke R. Gizewski,Hans-Christoph Diener,Mark Hallett,Matthias Maschke +6 more
TL;DR: The observed sensory overactivation suggests a general disinhibition of the somatosensory system in CD as it was not limited to the motor‐system or the direct neuronal representation of the affected dystonic musculature alone.
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Longitudinal studies of botulinum toxin in cervical dystonia: Why do patients discontinue therapy?
TL;DR: Longitudinal studies uniformly reveal botulinum toxin to be safe and effective in the treatment of cervical dystonia and recommend further efforts to optimize administration of BoNT to improve BoNT preparations to extend duration or reduce side effects.