Markus Loeffler

TL;DR: Rituximab added to six cycles of CHOP-like chemotherapy improved long-term outcomes for young patients with good-prognosis diffuse large-B-cell lymphoma and the definition of two prognostic subgroups allows a more refined therapeutic approach to these patients than does assessment by IPI alone.

TL;DR: Findings suggest that cooperation between ID3 inactivation and IG-MYC translocation is a hallmark of Burkitt lymphomagenesis.

TL;DR: The EU-funded BLUEPRINT consortium that will generate epigenomic maps of at least 100 different blood cell types aims to bridge the gap in current knowledge between individual components of the epigenome and their functional dynamics through state-of-the-art analysis in a defined set of primarily human hematopoietic cells from healthy and diseased individuals.

TL;DR: The sex- and gene-specific differences of less common cancer risks should be taken into account in cancer surveillance and prevention programs for patients with Lynch syndrome.

TL;DR: The results suggest IRF4 translocations to be primary alterations in a molecularly defined subset of GCB-derived lymphomas, suggesting that diversity in tumor biology might contribute to the age-dependent differences in prognosis of lymphoma.