T
Toshihiro Kumabe
Researcher at Kitasato University
Publications - 89
Citations - 3229
Toshihiro Kumabe is an academic researcher from Kitasato University. The author has contributed to research in topics: Glioma & Medulloblastoma. The author has an hindex of 17, co-authored 89 publications receiving 2240 citations. Previous affiliations of Toshihiro Kumabe include University of Tokyo & Hiroshima University.
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Journal ArticleDOI
Intertumoral Heterogeneity within Medulloblastoma Subgroups
Florence M.G. Cavalli,Marc Remke,Marc Remke,Marc Remke,Ladislav Rampášek,John Peacock,David Shih,Betty Luu,Livia Garzia,Jonathon Torchia,Carolina Nor,A. Sorana Morrissy,Sameer Agnihotri,Yuan Yao Thompson,Claudia M. Kuzan-Fischer,Hamza Farooq,Keren Isaev,Keren Isaev,Craig Daniels,Byung Kyu Cho,Seung-Ki Kim,Kyu-Chang Wang,Ji Yeoun Lee,Wiesława Grajkowska,Marta Perek-Polnik,Alexandre Vasiljevic,Cécile Faure-Conter,Anne Jouvet,Caterina Giannini,Amulya A. Nageswara Rao,Kay Ka Wai Li,Ho Keung Ng,Charles G. Eberhart,Ian F. Pollack,Ronald L. Hamilton,G. Yancey Gillespie,James M. Olson,James M. Olson,Sarah Leary,William A. Weiss,Boleslaw Lach,Boleslaw Lach,Lola B. Chambless,Reid C. Thompson,Michael K. Cooper,Rajeev Vibhakar,Peter Hauser,Marie Lise C. van Veelen,Johan M. Kros,Pim J. French,Young Shin Ra,Toshihiro Kumabe,Enrique López-Aguilar,Karel Zitterbart,Jaroslav Sterba,Gaetano Finocchiaro,Maura Massimino,Erwin G. Van Meir,Satoru Osuka,Tomoko Shofuda,Almos Klekner,Massimo Zollo,Jeffrey R. Leonard,Joshua B. Rubin,Nada Jabado,Steffen Albrecht,Steffen Albrecht,Jaume Mora,Timothy E. Van Meter,Shin Jung,Andrew S. Moore,Andrew R. Hallahan,Jennifer A. Chan,Daniela Pretti da Cunha Tirapelli,Carlos Gilberto Carlotti,Maryam Fouladi,José Pimentel,Claudia C. Faria,Ali G. Saad,Luca Massimi,Linda M. Liau,Helen Wheeler,Hideo Nakamura,Samer K. Elbabaa,Mario Perezpeña-Diazconti,Fernando Chico Ponce de León,Shenandoah Robinson,Michal Zapotocky,Alvaro Lassaletta,Annie Huang,Cynthia Hawkins,Uri Tabori,Eric Bouffet,Ute Bartels,Peter B. Dirks,James T. Rutka,Gary D. Bader,Jüri Reimand,Jüri Reimand,Anna Goldenberg,Vijay Ramaswamy,Michael D. Taylor +101 more
TL;DR: Similarity network fusion (SNF) applied to genome-wide DNA methylation and gene expression data across 763 primary samples identifies very homogeneous clusters of patients, supporting the presence of medulloblastoma subtypes.
Journal ArticleDOI
The whole-genome landscape of medulloblastoma subtypes
Paul A. Northcott,Paul A. Northcott,Ivo Buchhalter,Ivo Buchhalter,A. Sorana Morrissy,Volker Hovestadt,Joachim Weischenfeldt,Tobias Ehrenberger,Susanne Gröbner,Maia Segura-Wang,Thomas Zichner,Vasilisa A. Rudneva,Hans-Jörg Warnatz,Nikos Sidiropoulos,Aaron H. Phillips,Steven E. Schumacher,Kortine Kleinheinz,Sebastian M. Waszak,Serap Erkek,Serap Erkek,David T.W. Jones,Barbara C. Worst,Marcel Kool,Marc Zapatka,Natalie Jäger,Lukas Chavez,Barbara Hutter,Matthias Bieg,Nagarajan Paramasivam,Nagarajan Paramasivam,Michael Heinold,Michael Heinold,Zuguang Gu,Naveed Ishaque,Christina Jäger-Schmidt,Charles D. Imbusch,Alke Jugold,Daniel Hübschmann,Daniel Hübschmann,Daniel Hübschmann,Thomas Risch,Vyacheslav Amstislavskiy,Francisco German Rodriguez Gonzalez,Ursula D. Weber,Stephan Wolf,Giles W. Robinson,Xin Zhou,Gang Wu,David Finkelstein,Yanling Liu,Florence M.G. Cavalli,Betty Luu,Vijay Ramaswamy,Xiaochong Wu,Jan Koster,Marina Ryzhova,Yoon Jae Cho,Scott L. Pomeroy,Christel Herold-Mende,Martin U. Schuhmann,Martin Ebinger,Linda M. Liau,Jaume Mora,Roger E. McLendon,Nada Jabado,Toshihiro Kumabe,Eric Chuah,Yussanne Ma,Richard A. Moore,Andrew J. Mungall,Karen Mungall,Nina Thiessen,Kane Tse,Tina Wong,Steven J.M. Jones,Olaf Witt,Till Milde,Andreas von Deimling,David Capper,Andrey Korshunov,Marie-Laure Yaspo,Richard W. Kriwacki,Amar Gajjar,Jinghui Zhang,Rameen Beroukhim,Ernest Fraenkel,Jan O. Korbel,Benedikt Brors,Matthias Schlesner,Roland Eils,Roland Eils,Marco A. Marra,Stefan M. Pfister,Stefan M. Pfister,Michael D. Taylor,Peter Lichter +95 more
TL;DR: The application of integrative genomics to an extensive cohort of clinical samples derived from a single childhood cancer entity revealed a series of cancer genes and biologically relevant subtype diversity that represent attractive therapeutic targets for the treatment of patients with medulloblastoma.
Journal ArticleDOI
Divergent clonal selection dominates medulloblastoma at recurrence
A. Sorana Morrissy,Livia Garzia,David Shih,Scott Zuyderduyn,Xi Huang,Patryk Skowron,Marc Remke,Florence M.G. Cavalli,Vijay Ramaswamy,Patricia Lindsay,Salomeh Jelveh,Laura K. Donovan,Xin Wang,Betty Luu,Kory Zayne,Yisu Li,Chelsea Mayoh,Nina Thiessen,Eloi Mercier,Karen Mungall,Yusanne Ma,Kane Tse,Thomas Zeng,Karey Shumansky,Andrew Roth,Sohrab P. Shah,Hamza Farooq,Noriyuki Kijima,Borja L. Holgado,John J.Y. Lee,Stuart Matan-Lithwick,Jessica Liu,Stephen C. Mack,Stephen C. Mack,Alex Manno,K. A. Michealraj,Carolina Nor,John Peacock,Lei Qin,Jüri Reimand,Adi Rolider,Yuan Yao Thompson,Xiaochong Wu,Trevor J. Pugh,Adrian Ally,Mikhail Bilenky,Yaron S.N. Butterfield,Rebecca Carlsen,Young Cheng,Eric Chuah,Richard Corbett,Noreen Dhalla,An He,Darlene Lee,Haiyan I. Li,William Long,Michael Mayo,Patrick Plettner,Jenny Q. Qian,Jacqueline E. Schein,Angela Tam,Tina Wong,Inanc Birol,Inanc Birol,Yongjun Zhao,Claudia C. Faria,José Pimentel,Sofia Nunes,Tarek Shalaby,Michael A. Grotzer,Ian F. Pollack,Ronald L. Hamilton,Xiao-Nan Li,Anne Bendel,Daniel W. Fults,Andrew W. Walter,Toshihiro Kumabe,Teiji Tominaga,V. Peter Collins,Yoon Jae Cho,Caitlin Hoffman,David Lyden,Jeffrey H. Wisoff,James Garvin,Duncan Stearns,Luca Massimi,Ulrich Schüller,Jaroslav Sterba,Karel Zitterbart,Stéphanie Puget,Olivier Ayrault,Sandra E. Dunn,Daniela Pretti da Cunha Tirapelli,Carlos Gilberto Carlotti,Helen Wheeler,Andrew R. Hallahan,Wendy J. Ingram,Tobey J. MacDonald,Jeffrey J. Olson,Erwin G. Van Meir,Ji Yeoun Lee,Kyu-Chang Wang,Seung-Ki Kim,Byung Kyu Cho,Torsten Pietsch,Gudrun Fleischhack,Stephan Tippelt,Young Shin Ra,Simon Bailey,Janet C. Lindsey,Steven C. Clifford,Charles G. Eberhart,Michael K. Cooper,Roger J. Packer,Maura Massimino,Maria Luisa Garrè,Ute Bartels,Uri Tabori,Cynthia Hawkins,Peter B. Dirks,Eric Bouffet,James T. Rutka,Robert J. Wechsler-Reya,William A. Weiss,Lara S. Collier,Adam J. Dupuy,Andrey Korshunov,David T.W. Jones,Marcel Kool,Paul A. Northcott,Stefan M. Pfister,Stefan M. Pfister,David A. Largaespada,Andrew J. Mungall,Richard A. Moore,Nada Jabado,Gary D. Bader,Steven J.M. Jones,Steven J.M. Jones,David Malkin,Marco A. Marra,Michael D. Taylor +141 more
TL;DR: Targeted therapy is unlikely to be effective in the absence of the target, therefore the results offer a simple, proximal, and remediable explanation for the failure of prior clinical trials of targeted therapy.
Journal ArticleDOI
Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis
Eric M. Thompson,Eric M. Thompson,Thomas Hielscher,Eric Bouffet,Marc Remke,Betty Luu,Sridharan Gururangan,Roger E. McLendon,Darell D. Bigner,Eric S. Lipp,Sébastien Perreault,Yoon Jae Cho,Gerald A. Grant,Gerald A. Grant,Seung-Ki Kim,Ji Yeoun Lee,Amulya A. Nageswara Rao,Caterina Giannini,Kay Ka Wai Li,Ho Keung Ng,Yu Yao,Toshihiro Kumabe,Teiji Tominaga,Wiesława Grajkowska,Marta Perek-Polnik,David C.Y. Low,Wan Tew Seow,Kenneth Tou En Chang,Jaume Mora,Ian F. Pollack,Ronald L. Hamilton,Sarah Leary,Andrew S. Moore,Andrew S. Moore,Wendy J. Ingram,Andrew R. Hallahan,Andrew R. Hallahan,Anne Jouvet,Michelle Fèvre-Montange,Alexandre Vasiljevic,Cécile Faure-Conter,Tomoko Shofuda,Naoki Kagawa,Naoya Hashimoto,Nada Jabado,Alexander G. Weil,Tenzin Gayden,Takafumi Wataya,Tarek Shalaby,Michael A. Grotzer,Karel Zitterbart,Jaroslav Sterba,Leos Kren,Tibor Hortobágyi,Almos Klekner,Bognár László,Tímea Pócza,Peter Hauser,Ulrich Schüller,Shin Jung,Woo Youl Jang,Pim J. French,Johan M. Kros,Marie Lise C. van Veelen,Luca Massimi,Jeffrey R. Leonard,Joshua B. Rubin,Rajeev Vibhakar,Lola B. Chambless,Michael K. Cooper,Reid C. Thompson,Claudia C. Faria,Alice Carvalho,Sofia Nunes,José Pimentel,Xing Fan,Karin M. Muraszko,Enrique López-Aguilar,David Lyden,Livia Garzia,David Shih,Noriyuki Kijima,Christian Schneider,Jennifer Adamski,Paul A. Northcott,Marcel Kool,David T.W. Jones,Jennifer A. Chan,Ana Nikolic,Maria Luisa Garrè,Erwin G. Van Meir,Satoru Osuka,Jeffrey J. Olson,Arman Jahangiri,Brandyn A. Castro,Nalin Gupta,William A. Weiss,Iska Moxon-Emre,Donald J. Mabbott,Alvaro Lassaletta,Cynthia Hawkins,Uri Tabori,James M. Drake,Abhaya V. Kulkarni,Peter B. Dirks,James T. Rutka,Andrey Korshunov,Stefan M. Pfister,Stefan M. Pfister,Roger J. Packer,Vijay Ramaswamy,Michael D. Taylor +111 more
TL;DR: A re-evaluation of the long-term implications of intensified craniospinal irradiation in children with small residual portions of medulloblastoma is suggested as the marked benefit of EOR in the overall cohort was greatly attenuated after including molecular subgroup in the multivariable analysis.
Journal ArticleDOI
Recurrent noncoding U1 snRNA mutations drive cryptic splicing in SHH medulloblastoma
Hiromichi Suzuki,Sachin Kumar,Shimin Shuai,Shimin Shuai,Ander Diaz-Navarro,Ana Gutiérrez-Fernández,Pasqualino De Antonellis,Florence M.G. Cavalli,Kyle Juraschka,Hamza Farooq,Ichiyo Shibahara,Maria C. Vladoiu,Jiao Zhang,Namal Abeysundara,David Przelicki,Patryk Skowron,Nicole Gauer,Betty Luu,Craig Daniels,Xiaochong Wu,Antoine Forget,Antoine Forget,Ali Momin,Jun Wang,Weifan Dong,Seung-Ki Kim,Wiesława Grajkowska,Anne Jouvet,Michelle Fèvre-Montange,Maria Luisa Garrè,Amulya A. Nageswara Rao,Caterina Giannini,Johan M. Kros,Pim J. French,Nada Jabado,Ho Keung Ng,Wai Sang Poon,Charles G. Eberhart,Ian F. Pollack,James M. Olson,William A. Weiss,Toshihiro Kumabe,Enrique López-Aguilar,Boleslaw Lach,Boleslaw Lach,Maura Massimino,Erwin G. Van Meir,Joshua B. Rubin,Rajeev Vibhakar,Lola B. Chambless,Noriyuki Kijima,Almos Klekner,László Bognár,Jennifer A. Chan,Claudia C. Faria,Jiannis Ragoussis,Stefan M. Pfister,Stefan M. Pfister,Anna Goldenberg,Robert J. Wechsler-Reya,Robert J. Wechsler-Reya,Swneke D. Bailey,Livia Garzia,A. Sorana Morrissy,Marco A. Marra,Xi Huang,David Malkin,Olivier Ayrault,Olivier Ayrault,Vijay Ramaswamy,Xose S. Puente,John A. Calarco,Lincoln Stein,Michael D. Taylor +73 more
TL;DR: These U1 snRNA mutations provide an example of highly recurrent and tissue-specific mutations of a non-protein-coding gene in cancer, which result in disrupted RNA splicing and the activation of oncogenes.