M
Marylene Leboeuf
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 32
Citations - 13832
Marylene Leboeuf is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Dendritic cell & Macrophage. The author has an hindex of 27, co-authored 31 publications receiving 11712 citations.
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Journal ArticleDOI
Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
Florent Ginhoux,Florent Ginhoux,Melanie Greter,Marylene Leboeuf,Sayan Nandi,Peter See,Solen Gokhan,Mark F. Mehler,Simon J. Conway,Lai Guan Ng,E. Richard Stanley,Igor M. Samokhvalov,Miriam Merad +12 more
TL;DR: Results identify microglia as an ontogenically distinct population in the mononuclear phagocyte system and have implications for the use of embryonically derived microglial progenitors for the treatment of various brain disorders.
Journal ArticleDOI
Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes
Daigo Hashimoto,Andrew Chow,Andrew Chow,Clara Noizat,Clara Noizat,Pearline Teo,Mary Beth Beasley,Marylene Leboeuf,Christian Becker,Peter See,Jeremy Price,Daniel Lucas,Melanie Greter,Melanie Greter,Arthur Mortha,Scott W. Boyer,E. Camilla Forsberg,Masato Tanaka,Nico van Rooijen,Adolfo García-Sastre,E. Richard Stanley,Florent Ginhoux,Paul S. Frenette,Miriam Merad +23 more
TL;DR: Results indicate that tissue-resident macrophages and circulating monocytes should be classified as mononuclear phagocyte lineages that are independently maintained in the steady state.
Journal ArticleDOI
Origin of the lamina propria dendritic cell network.
Milena Bogunovic,Florent Ginhoux,Julie Helft,Limin Shang,Daigo Hashimoto,Melanie Greter,Kang Liu,Claudia Jakubzick,Molly A. Ingersoll,Marylene Leboeuf,E. Richard Stanley,Michel C. Nussenzweig,Sergio A. Lira,Gwendalyn J. Randolph,Miriam Merad +14 more
TL;DR: It is shown that monocytes gave rise exclusively to CD103(-)CX(3)CR1(+) lamina propria DCs under the control of macrophage-colony-stimulating factor receptor (M-CSFR) and Fms-like thyrosine kinase 3 (Flt3) ligands.
Journal ArticleDOI
Expansion and Activation of CD103(+) Dendritic Cell Progenitors at the Tumor Site Enhances Tumor Responses to Therapeutic PD-L1 and BRAF Inhibition.
Hélène Salmon,Juliana Idoyaga,Adeeb Rahman,Marylene Leboeuf,Romain Remark,Stefan Jordan,Maria Casanova-Acebes,Makhzuna Khudoynazarova,Judith Agudo,Navpreet Tung,Svetoslav Chakarov,Christina Rivera,Brandon Hogstad,Marcus Bosenberg,Daigo Hashimoto,Sacha Gnjatic,Nina Bhardwaj,Anna Karolina Palucka,Brian D. Brown,Joshua Brody,Florent Ginhoux,Miriam Merad +21 more
TL;DR: The paucity of activated CD103(+) DCs in tumors limits checkpoint-blockade efficacy and combined FLT3L and poly I:C therapy can enhance tumor responses to checkpoint and BRAF blockade.
Journal ArticleDOI
Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche
Andrew Chow,Daniel Lucas,Daniel Lucas,Andrés Hidalgo,Andrés Hidalgo,Simón Méndez-Ferrer,Simón Méndez-Ferrer,Daigo Hashimoto,Christoph Scheiermann,Christoph Scheiermann,Michela Battista,Marylene Leboeuf,Colette Prophete,Colette Prophete,Nico van Rooijen,Masato Tanaka,Miriam Merad,Paul S. Frenette,Paul S. Frenette +18 more
TL;DR: Results highlight two antagonistic, tightly balanced pathways that regulate maintenance of HSCs/progenitors in the niche during homeostasis, in which MΦ cross talk with the Nestin+ niche cell promotes retention, and in contrast, SNS signals enhance egress.