M
Mayda Gursel
Researcher at Middle East Technical University
Publications - 72
Citations - 8482
Mayda Gursel is an academic researcher from Middle East Technical University. The author has contributed to research in topics: CpG site & CpG Oligodeoxynucleotide. The author has an hindex of 32, co-authored 68 publications receiving 6904 citations. Previous affiliations of Mayda Gursel include Center for Biologics Evaluation and Research & Food and Drug Administration.
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Journal ArticleDOI
Biological properties of extracellular vesicles and their physiological functions
María Yáñez-Mó,Pia Siljander,Zoraida Andreu,Apolonija Bedina Zavec,Francesc E. Borràs,Edit I. Buzás,Krisztina Buzas,Krisztina Buzas,Enriqueta Casal,Francesco Cappello,Joana Carvalho,Joana Carvalho,Eva Colas,Anabela Cordeiro da Silva,Anabela Cordeiro da Silva,Stefano Fais,Juan M. Falcón-Pérez,Irene M. Ghobrial,Bernd Giebel,Mario Gimona,Mario Gimona,Michael W. Graner,Ihsan Gursel,Mayda Gursel,Niels H. H. Heegaard,Niels H. H. Heegaard,An Hendrix,Peter Kierulf,Katsutoshi Kokubun,Maja Kosanović,Veronika Kralj-Iglič,Eva-Maria Krämer-Albers,Saara Laitinen,Cecilia Lässer,Thomas Lener,Thomas Lener,Erzsébet Ligeti,Aija Linē,Georg Lipps,Alicia Llorente,Jan Lötvall,Mateja Manček-Keber,Antonio Marcilla,María Mittelbrunn,Irina Nazarenko,Esther N. M. Nolte-‘t Hoen,Tuula A. Nyman,Lorraine O'Driscoll,Mireia Olivan,Carla Oliveira,Carla Oliveira,Éva Pállinger,Hernando A. del Portillo,Hernando A. del Portillo,Jaume Reventós,Jaume Reventós,Marina Rigau,Eva Rohde,Eva Rohde,Marei Sammar,Francisco Sánchez-Madrid,Nuno Santarém,Nuno Santarém,Katharina Schallmoser,Katharina Schallmoser,Marie Stampe Ostenfeld,Willem Stoorvogel,Roman Štukelj,Susanne G. van der Grein,M. Helena Vasconcelos,M. Helena Vasconcelos,Marca H. M. Wauben,Olivier De Wever +72 more
TL;DR: A comprehensive overview of the current understanding of the physiological roles of EVs is provided, drawing on the unique EV expertise of academia-based scientists, clinicians and industry based in 27 European countries, the United States and Australia.
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Cutting Edge: Role of Toll-Like Receptor 9 in CpG DNA-Induced Activation of Human Cells
Fumihiko Takeshita,Cynthia A. Leifer,Ihsan Gursel,Ken Ishii,Saoko Takeshita,Mayda Gursel,Dennis M. Klinman +6 more
TL;DR: Findings indicate that hTLR9 plays a critical role in the CpG DNA-mediated activation of human cells and evolutionary divergence between TLR9 molecules underlies species-specific differences in the recognition of bacterial DNA.
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Human Peripheral Blood Cells Differentially Recognize and Respond to Two Distinct CpG Motifs
TL;DR: Analysis of hundreds of novel ODN resulted in the identification and characterization of two structurally distinct “clusters” of immunostimulatory CpG ODN that preferentially stimulates IFN-γ production by NK cells, whereas the other (“K”) stimulates cell proliferation and the production of IL-6 and IgM by monocytes and B cells.
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Differential and competitive activation of human immune cells by distinct classes of CpG oligodeoxynucleotide
TL;DR: It is established that both types of ODN bind to and are internalized by the same individual B cells, NK cells, and monocytes, and that different types of CpG ODN have distinct and in some cases incompatible effects on the same cells.
Journal ArticleDOI
Repetitive Elements in Mammalian Telomeres Suppress Bacterial DNA-Induced Immune Activation
TL;DR: It is found that repetitive elements present at high frequency in mammalian telomeres, but rare in bacteria, down-regulate CpG-induced immune activation and correlates with the ability of telomeric TTAGGG repeats to form G-tetrads.