M
Michael Detmar
Researcher at École Polytechnique Fédérale de Lausanne
Publications - 351
Citations - 43193
Michael Detmar is an academic researcher from École Polytechnique Fédérale de Lausanne. The author has contributed to research in topics: Lymphatic system & Lymphangiogenesis. The author has an hindex of 94, co-authored 334 publications receiving 39086 citations. Previous affiliations of Michael Detmar include Harvard University & Beth Israel Deaconess Medical Center.
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Thrombospondin-1 selectively inhibits early-stage carcinogenesis and angiogenesis but not tumor lymphangiogenesis and lymphatic metastasis in transgenic mice.
Thomas Hawighorst,Hajimu Oura,Michael Streit,Lauren Janes,Lynh Nguyen,Lawrence F. Brown,Guillermo Oliver,David A. Jackson,Michael Detmar +8 more
TL;DR: Overexpression of TSP-1 resulted in delayed and reduced development of premalignant epithelial hyperplasias, but did not inhibit the malignant conversion to squamous cell carcinomas, and the endothelial T SP-1 receptor CD36 was mostly absent from cutaneous lymphatic vessels.
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Multifocal lymphangioendotheliomatosis with thrombocytopenia: a newly recognized clinicopathological entity.
TL;DR: The term multifocal lymphangioendotheliomatosis with thrombocytopenia is proposed to distinguish this newly recognized clinicopathological entity for congenital lesions that show lymphatic differentiation, strengthening the association between abnormal lymphatic endothelium and coagulopathy.
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Galectin-8 interacts with podoplanin and modulates lymphatic endothelial cell functions.
Leah N. Cueni,Michael Detmar +1 more
TL;DR: A role for galectin-8 and podoplanin in supporting the connection of the lymphatic endothelium to the surrounding extracellular matrix, most likely in cooperation with other glycoproteins on the surface of lymphatic vascular endothelial cells is suggested.
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Tumor-Associated Lymphatic Vessels Upregulate PDL1 to Inhibit T-Cell Activation
Lothar C. Dieterich,Kristian Ikenberg,Timur Cetintas,Kübra Kapaklikaya,Cornelia Hutmacher,Michael Detmar +5 more
TL;DR: In this paper, tumor-associated lymphatic vessels (LVs) play multiple roles during tumor progression, including promotion of metastasis and regulation of antitumor immune responses by delivering antigen from the tumor bed to draining lymph nodes (LNs).
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Targeted Overexpression of the Angiogenesis Inhibitor Thrombospondin-1 in the Epidermis of Transgenic Mice Prevents Ultraviolet-B-Induced Angiogenesis and Cutaneous Photo-Damage
TL;DR: An important role of the cutaneous vascular system is revealed in mediating ultraviolet-B-induced skin damage and inhibition of angiogenesis is suggested as a potential new approach for the prevention of chronic cutaneous photo-damage.