M
Michael Detmar
Researcher at École Polytechnique Fédérale de Lausanne
Publications - 351
Citations - 43193
Michael Detmar is an academic researcher from École Polytechnique Fédérale de Lausanne. The author has contributed to research in topics: Lymphatic system & Lymphangiogenesis. The author has an hindex of 94, co-authored 334 publications receiving 39086 citations. Previous affiliations of Michael Detmar include Harvard University & Beth Israel Deaconess Medical Center.
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Journal ArticleDOI
Pheophorbide a identified in an Eupatorium perfoliatum extract is a novel lymphatic vascular activator.
Jihye Kim,Epameinondas Gousopoulos,Teresa Faleschini,Matthias Hamburger,Olivier Potterat,Michael Detmar +5 more
TL;DR: In this paper , a petroleum ether extract from aerial parts of Eupatorium perfoliatum (E. perfolia) was found to possess lymphangiogenic properties.
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Keratinocyte-Expressed Podoplanin is Dispensable for Multi-Step Skin Carcinogenesis.
TL;DR: Keratinocyte-expressed podoplanin is dispensable for the early steps of skin carcinogenesis but contributes to the progression of established tumors, as revealed by Quantitative immunofluorescence analyses.
Journal Article
Bacillary epithelioid angiomatosis in advanced HIV infection
TL;DR: A patient with advanced HIV infection developed multiple angiomatous papules and nodules on the upper chest within a few days that resembled disseminated Kaposi's sarcoma; the differential diagnosis included eruptive haemangiomas and pyogenic granulomas.
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Novel Blood Vascular Endothelial Subtype-Specific Markers in Human Skin Unearthed by Single-Cell Transcriptomic Profiling
Yuliang He,Carlotta Tacconi,Lothar C. Dieterich,Jihye Kim,Gaetana Restivo,Epameinondas Gousopoulos,Nicole Lindenblatt,Mitchell P. Levesque,Manfred Claassen,Michael Detmar +9 more
TL;DR: This study molecularly refines individual BV compartments, whilst the identification of novel subtype-specific signatures provides more insights for future studies dissecting the responses of distinct vessel segments under pathological conditions.
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Immunomodulatory Responses of Subcapsular Sinus Floor Lymphatic Endothelial Cells in Tumor-Draining Lymph Nodes
Eliane Sibler,Yuliang He,Luca Ducoli,Viviane Rihs,Patrick Sidler,Claudia Puig-Moreno,Jasmin Renate Elisabeth Frey,Noriki Fujimoto,Michael Detmar,Lothar C. Dieterich +9 more
TL;DR: Tumor-draining lymph nodes, composed of lymphocytes, antigen-presenting cells, and stromal cells, are highly relevant for tumor immunity and the efficacy of immunotherapies and data show that tumor-derived factors induce transcriptional changes in LECs of the draining LNs, especially the fLECs, and that these changes may affect tumor immunity.