M
Michael Detmar
Researcher at École Polytechnique Fédérale de Lausanne
Publications - 351
Citations - 43193
Michael Detmar is an academic researcher from École Polytechnique Fédérale de Lausanne. The author has contributed to research in topics: Lymphatic system & Lymphangiogenesis. The author has an hindex of 94, co-authored 334 publications receiving 39086 citations. Previous affiliations of Michael Detmar include Harvard University & Beth Israel Deaconess Medical Center.
Papers
More filters
Journal ArticleDOI
Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice.
TL;DR: It is shown that the major outflow pathway for CSF in mice are lymphatic vessels and that this drainage decreases as the mice age, suggesting that the lymphatic system may represent a target for age-associated neurological conditions.
Journal ArticleDOI
An integrated expression atlas of miRNAs and their promoters in human and mouse.
Derek De Rie,Imad Abugessaisa,Tanvir Alam,Erik Arner,Peter Arner,Haitham Ashoor,Gaby Åström,Magda Babina,Nicolas Bertin,A. Maxwell Burroughs,Ailsa J Carlisle,Carsten O. Daub,Michael Detmar,Ruslan Deviatiiarov,Alexandre Fort,Claudia Gebhard,Dan Goldowitz,Sven Guhl,Thomas J. Ha,Jayson Harshbarger,Akira Hasegawa,Kosuke Hashimoto,Meenhard Herlyn,Peter Heutink,Kelly J Hitchens,Chung-Chau Hon,Edward Huang,Edward Huang,Yuri Ishizu,Chieko Kai,Takeya Kasukawa,Peter S Klinken,Timo Lassmann,Charles-Henri Lecellier,Weon Ju Lee,Marina Lizio,Vsevolod J. Makeev,Vsevolod J. Makeev,Vsevolod J. Makeev,Anthony Mathelier,Yulia A. Medvedeva,Niklas Mejhert,Christopher J. Mungall,Shohei Noma,Mitsuhiro Ohshima,Mariko Okada-Hatakeyama,Helena Persson,Patrizia Rizzu,Filip Roudnicky,Pål Sætrom,Hiroki Sato,Jessica Severin,Jay W. Shin,Rolf Swoboda,Hiroshi Tarui,Hiroo Toyoda,Kristoffer Vitting-Seerup,Louise N. Winteringham,Yoko Yamaguchi,Kayoko Yasuzawa,Misako Yoneda,Noriko Yumoto,Susan Zabierowski,Peter G. Zhang,Christine A. Wells,Christine A. Wells,Kim M. Summers,Kim M. Summers,Hideya Kawaji,Albin Sandelin,Michael Rehli,Yoshihide Hayashizaki,Piero Carninci,Alistair R. R. Forrest,Michiel J. L. de Hoon +74 more
TL;DR: An integrated expression atlas of miRNAs and their promoters by deep-sequencing 492 short RNA libraries, with matching Cap Analysis Gene Expression (CAGE) data, is created, establishing a foundation for detailed analysis of miRNA expression patterns and transcriptional control regions.
Journal ArticleDOI
Concurrent induction of lymphangiogenesis, angiogenesis, and macrophage recruitment by vascular endothelial growth factor-C in melanoma.
Mihaela Skobe,Leena Hamberg,Thomas Hawighorst,Michael Schirner,Gerald L. Wolf,Kari Alitalo,Michael Detmar +6 more
TL;DR: The presence of intratumoral lymphatics and enlargement of lymphatic vessels at the tumor periphery in vascular endothelial growth factor (VEGF)-C-overexpressing human melanomas transplanted onto nude mice is demonstrated and VEGF-C is identified as multifunctional factor involved in regulating tumor lymphangiogenesis, angiogenic, and immune response.
Journal ArticleDOI
The rediscovery of the lymphatic system: old and new insights into the development and biological function of the lymphatic vasculature
Guillermo Oliver,Michael Detmar +1 more
TL;DR: The lymphatic system is composed of a vascular network of thin-walled capillaries that drain protein-rich lymph from the extracellular spaces within most organs, and lymphatic vessels are not normally present in avascular structures such as epidermis, hair, nails, cartilage, and cornea.
Journal ArticleDOI
Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus.
Young-Kwon Hong,Kimberly E. Foreman,Jay W. Shin,Satoshi Hirakawa,Christine L. Curry,David R. Sage,Towia A. Libermann,Bruce J. Dezube,Joyce D. Fingeroth,Michael Detmar +9 more
TL;DR: It is shown that infection of differentiated blood vascular endothelial cells with Kaposi sarcoma–associated herpesvirus leads to their lymphatic reprogramming; induction of ∼70% of the main lymphatic lineage–specific genes, including PROX1, a master regulator of lymphatic development; and downregulation of blood vascular genes.