M
Michael Detmar
Researcher at École Polytechnique Fédérale de Lausanne
Publications - 351
Citations - 43193
Michael Detmar is an academic researcher from École Polytechnique Fédérale de Lausanne. The author has contributed to research in topics: Lymphatic system & Lymphangiogenesis. The author has an hindex of 94, co-authored 334 publications receiving 39086 citations. Previous affiliations of Michael Detmar include Harvard University & Beth Israel Deaconess Medical Center.
Papers
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Journal ArticleDOI
High-Fat Diet in the Absence of Obesity Does Not Aggravate Surgically Induced Lymphoedema in Mice.
Epameinondas Gousopoulos,Sinem Karaman,Steven T. Proulx,Kristin Leu,Dorina Buschle,Michael Detmar +5 more
TL;DR: Increased adiposity rather than dietary influences determines predisposition to or severity of lymphedema, as indicated by results of a mouse tail lymphoedema model.
Book ChapterDOI
Molecular Mechanisms of Lymph Node Metastasis
TL;DR: Results indicate that tumors can also induce lymphatic vessel growth in sentinel lymph nodes, even before the onset of metastasis, and that lymph node lymphangiogenesis further promotes cancer spread to distant lymph nodes and to distant organs.
Journal ArticleDOI
Growth characteristics and differentiation of basal cell carcinoma in vitro--immunohistochemical, gel electrophoretic, and ultrastructural analysis.
Maki Asada,Frank-Matthias Schaart,Michael Detmar,Dietmar Mischke,Hiram L de Almeida,Harald Gollnick,Constantin E. Orfanos +6 more
TL;DR: It is indicated that cultured BCC cells may preserve in vitro some in vivo characteristics and maintain a growth and differentiation pattern that differs from cultured nKC.
Journal ArticleDOI
Mutation of Threonine 34 in Mouse Podoplanin-Fc Reduces CLEC-2 Binding and Toxicity in Vivo While Retaining Anti-lymphangiogenic Activity
Roberta Bianchi,Eliane Fischer,Don Yuen,Ellen Ernst,Alexandra Michaela Ochsenbein,Lu Chen,Vivianne I. Otto,Michael Detmar +7 more
TL;DR: The data suggest that the function of PdPN in lymphangiogenesis does not depend on threonine 34 in the CLEC-2 binding domain and that PdpnT34A-Fc might be an improved inhibitor of lymphang iogenesis with fewer toxic side effects.
Book ChapterDOI
In vivo imaging of lymph node lymphangiogenesis by immuno-positron emission tomography.
Viviane Mumprecht,Michael Detmar +1 more
TL;DR: A noninvasive methodology is presented to image lymphangiogenesis in vivo in mice based on the intravenous injection of a radioactively labeled antibody against the lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1), which is almost exclusively expressed on lymphatic vessels.