M
Michael Detmar
Researcher at École Polytechnique Fédérale de Lausanne
Publications - 351
Citations - 43193
Michael Detmar is an academic researcher from École Polytechnique Fédérale de Lausanne. The author has contributed to research in topics: Lymphatic system & Lymphangiogenesis. The author has an hindex of 94, co-authored 334 publications receiving 39086 citations. Previous affiliations of Michael Detmar include Harvard University & Beth Israel Deaconess Medical Center.
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Journal Article
Systemic inhibition of tumor growth and angiogenesis by thrombospondin-2 using cell-based antiangiogenic gene therapy.
Michael Streit,Antonia E. Stephen,Thomas Hawighorst,Kant Matsuda,Bernhard Lange-Asschenfeldt,Lawrence F. Brown,Joseph P. Vacanti,Michael Detmar +7 more
TL;DR: A tissue-engineered implant system for the continuous in vivo production of thrombospondin-2 (TSP-2), a potent endogenous inhibitor of tumor growth and angiogenesis, provides the first proof-of-principle for the feasibility and therapeutic efficiency of systemic, cell-based antiangiogenic gene therapy using biodegradable polymer grafts for the treatment of cancer.
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Expression of the Type-1 Repeats of Thrombospondin-1 Inhibits Tumor Growth Through Activation of Transforming Growth Factor-β
TL;DR: The findings suggest that the inhibition of tumor angiogenesis and growth by endogenous TSP-1 involves regulation of both active and total TGF-beta and the sequences KRFK and WSHWSPW in the second type-1 repeat.
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Regulatory T cell transfer ameliorates lymphedema and promotes lymphatic vessel function
Epameinondas Gousopoulos,Steven T. Proulx,Samia B. Bachmann,Jeannette Scholl,Dimitris Dionyssiou,Efterpi Demiri,Cornelia Halin,Lothar C. Dieterich,Michael Detmar +8 more
TL;DR: Therapeutic application of adoptively transferred Tregs upon lymphedema establishment reversed all of the major hallmarks of lympherema, including edema, inflammation, and fibrosis, and also promoted lymphatic drainage function.
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Culture of human sebocytes and markers of sebocytic differentiation in vitro.
Christos C. Zouboulis,Longqing Xia,Michael Detmar,Birgit Bogdanoff,Georgios Giannakopoulos,Harald Gollnick,Constantin E. Orfanos +6 more
TL;DR: The culture of human sebocytes possessing several characteristics of sebocytic differentiation in vivo offers unique possibilities in investigating direct effects on sebaceous cell growth, differentiation and their regulation.
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Induction of lymphatic endothelial cell differentiation in embryoid bodies
TL;DR: The results reveal, for the first time, that ES cells can differentiate into lymphatic endothelial cells, and they identify the EB assay as a powerful new tool to dissect the molecular mechanisms that control lymphatic vessel formation.