M
Michael Detmar
Researcher at École Polytechnique Fédérale de Lausanne
Publications - 351
Citations - 43193
Michael Detmar is an academic researcher from École Polytechnique Fédérale de Lausanne. The author has contributed to research in topics: Lymphatic system & Lymphangiogenesis. The author has an hindex of 94, co-authored 334 publications receiving 39086 citations. Previous affiliations of Michael Detmar include Harvard University & Beth Israel Deaconess Medical Center.
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Journal ArticleDOI
Cytokine regulation of proliferation and ICAM-1 expression of human dermal microvascular endothelial cells in vitro.
TL;DR: IL-1 is disclosed as a major, multifunctional endothelial cell-targeted cytokine and the concept that pro-inflammatory cytokines exert differential regulatory effects on dermal microvascular endothelial cells proliferation and expression of cell-adhesion molecules is confirmed.
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Vascular endothelial growth factor-C (VEGF-C) and its receptors KDR and flt-4 are expressed in AIDS-associated Kaposi's sarcoma.
Mihaela Skobe,Lawrence F. Brown,Kathi Tognazzi,Ramesh K. Ganju,Bruce J. Dezube,Kari Alitalo,Michael Detmar +6 more
TL;DR: Important paracrine functions of vascular endothelial growth factor-C, produced by blood vessels, in the pathogenesis of cutaneous Kaposi's sarcoma are demonstrated and suggested, suggesting a lymphatic origin and/or differentiation of Kaposi' s Sarcoma tumor cells.
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Prox1, master regulator of the lymphatic vasculature phenotype.
Young-Kwon Hong,Michael Detmar +1 more
TL;DR: These studies suggest that the blood vascular phenotype represents the default endothelial differentiation and they identify an essential role of Prox1 in the program specifying lymphatic endothelial cell fate.
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Tumor lymphangiogenesis and metastasis to lymph nodes induced by cancer cell expression of podoplanin.
Leah N. Cueni,Ivan Hegyi,Jay W. Shin,Andrea Albinger-Hegyi,S. Gruber,Rainer Kunstfeld,Holger Moch,Michael Detmar +7 more
TL;DR: It is found that podoplanin expression promoted tumor cell motility in vitro and, unexpectedly, increased tumor lymphangiogenesis and metastasis to regional lymph nodes in vivo, without promoting primary tumor growth.
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An Unexpected Role of Semaphorin3A/Neuropilin-1 Signaling in Lymphatic Vessel Maturation and Valve Formation
Giorgia Jurisic,Hélène Maby-El Hajjami,Sinem Karaman,Alexandra M. Ochsenbein,Annamari Alitalo,Shoib S. Siddiqui,Carlos Ochoa Pereira,Tatiana V. Petrova,Michael Detmar +8 more
TL;DR: Together, these results reveal an unanticipated role of Sema3A–Nrp-1 signaling in the maturation of the lymphatic vascular network likely via regulating the perivascular cell coverage of the vessels thus affecting lymphatic vessel function and lymphatic valve development.