M
Michael Detmar
Researcher at École Polytechnique Fédérale de Lausanne
Publications - 351
Citations - 43193
Michael Detmar is an academic researcher from École Polytechnique Fédérale de Lausanne. The author has contributed to research in topics: Lymphatic system & Lymphangiogenesis. The author has an hindex of 94, co-authored 334 publications receiving 39086 citations. Previous affiliations of Michael Detmar include Harvard University & Beth Israel Deaconess Medical Center.
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Journal ArticleDOI
Control of hair growth and follicle size by VEGF-mediated angiogenesis
TL;DR: These results identify VEGF as a major mediator of hair follicle growth and cycling and provide the first direct evidence that improved follicle vascularization promotes hair growth and increases hair follicles and hair size.
Journal ArticleDOI
Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells
Erik Arner,Carsten O. Daub,Kristoffer Vitting-Seerup,Robin Andersson,Berit Lilje,Finn Drabløs,Andreas Lennartsson,Michelle Rönnerblad,Olga Hrydziuszko,Morana Vitezic,Tom C. Freeman,Ahmad M. N. Alhendi,Peter Arner,Richard A Axton,J Kenneth Baillie,Anthony G Beckhouse,Beatrice Bodega,James Briggs,Frank Brombacher,Margaret B. Davis,Michael Detmar,Anna Ehrlund,Mitsuhiro Endoh,Afsaneh Eslami,Michela Fagiolini,Lynsey Fairbairn,Geoffrey J. Faulkner,Carmelo Ferrai,Malcolm E. Fisher,Lesley M. Forrester,Dan Goldowitz,Reto Guler,Thomas J. Ha,Mitsuko Hara,Meenhard Herlyn,Tomokatsu Ikawa,Chieko Kai,Hiroshi Kawamoto,Levon M. Khachigian,S. Peter Klinken,Soichi Kojima,Haruhiko Koseki,Sarah Klein,Niklas Mejhert,Ken Miyaguchi,Yosuke Mizuno,Mitsuru Morimoto,Kelly J. Morris,Christine L. Mummery,Yutaka Nakachi,Soichi Ogishima,Mariko Okada-Hatakeyama,Yasushi Okazaki,Valerio Orlando,Dmitry A. Ovchinnikov,Robert Passier,Margaret Patrikakis,Ana Pombo,Xian-Yang Qin,Sugata Roy,Hiroki Sato,Suzana Savvi,Alka Saxena,Anita Schwegmann,Daisuke Sugiyama,Rolf Swoboda,Hiroshi Tanaka,Andru Tomoiu,Louise N. Winteringham,Ernst J. Wolvetang,Chiyo Yanagi-Mizuochi,Misako Yoneda,Susan E. Zabierowski,Peter G. Zhang,Imad Abugessaisa,Nicolas Bertin,Alexander D. Diehl,Shiro Fukuda,Masaaki Furuno,Jayson Harshbarger,Akira Hasegawa,Fumi Hori,Sachi Ishikawa-Kato,Yuri Ishizu,Masayoshi Itoh,Tsugumi Kawashima,Miki Kojima,Naoto Kondo,Marina Lizio,Terrence F. Meehan,Christopher J. Mungall,Mitsuyoshi Murata,Hiromi Nishiyori-Sueki,Serkan Sahin,Sayaka Nagao-Sato,Jessica Severin,Michiel J. L. de Hoon,Jun Kawai,Takeya Kasukawa,Timo Lassmann,Harukazu Suzuki,Hideya Kawaji,Kim M. Summers,Christine A. Wells,David A. Hume,Alistair R. R. Forrest,Albin Sandelin,Piero Carninci,Yoshihide Hayashizaki +108 more
TL;DR: The data support a highly generalizable model in which enhancer transcription is the earliest event in successive waves of transcriptional change during cellular differentiation or activation.
Journal ArticleDOI
Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate.
Young-Kwon Hong,Natasha L. Harvey,Yun Hee Noh,Vivien Schacht,Satoshi Hirakawa,Michael Detmar,Guillermo Oliver +6 more
TL;DR: It is confirmed that Prox1 is a key player in the molecular pathway leading to the formation of lymphatic vasculature and identified as a master switch in the program specifying lymphatic endothelial cell fate, and that a single gene product was sufficient to re‐program the blood vascular endothelium toward a lymphatic phenotype.
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Angiogenesis promoted by vascular endothelial growth factor: regulation through alpha1beta1 and alpha2beta1 integrins.
Donald R. Senger,Kevin P. Claffey,Julie E. Benes,Carole A. Perruzzi,Ageliki P. Sergiou,Michael Detmar +5 more
TL;DR: Induction of alpha1beta1 and alpha2beta1 expression by EC is an important mechanism by which VEGF promotes angiogenesis and that alpha1 beta1 andalpha2 beta1 antagonists may prove effective in inhibiting V EGF-driven angiogenic in cancers and other important pathologies.
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Tumor Lymphangiogenesis : A Novel Prognostic Indicator for Cutaneous Melanoma Metastasis and Survival
Soheil S. Dadras,Thomas Paul,Jennifer Bertoncini,Lawrence F. Brown,Alona Muzikansky,David A. Jackson,U. Ellwanger,Claus Garbe,Martin C. Mihm,Michael Detmar +9 more
TL;DR: Tumor lymphangiogenesis is revealed as a novel prognostic indicator for the risk of lymph node metastasis in cutaneous melanoma.