Michael Detmar

TL;DR: Results indicate that antibodies specific to components of the modified extracellular matrix can selectively accumulate at chronically inflamed sites in vivo, and stimulates the search for bioactive molecules which can be fused to antibodies and which may confer a therapeutic benefit as a result of their preferential accumulation in psoriatic lesions and other sites of inflammation.

TL;DR: The ability of AutoTube to determine vascular parameters in close agreement to the manual analyses and to identify statistically significant differences in vascular morphology in tissues and in vascular networks formed in in vitro assays is demonstrated.

TL;DR: It is found that MAFB, a TF involved in differentiation of various cell types, is rapidly induced and activated by VEGF-C, indicating a role in the maintenance of the mature LEC phenotype.

TL;DR: Novel therapeutic strategies are currently being developed that aim at inhibiting or promoting the formation and function of lymphatic vessels in disease.

TL;DR: An important role of podoplanin expressed by lymphatic vessels is revealed in preventing postnatal blood filling of the lymphatic vascular system and in contributing to efficient dendritic cell migration to the lymph nodes.