Daria Barwinska

TL;DR: The Kidney Precision Medicine Project (KMP) as discussed by the authors aims to ethically and safely obtain kidney biopsies from participants with chronic kidney disease (CKD) or acute kidney injury (AKI) and create a reference kidney atlas, and characterize disease subgroups to stratify patients based on molecular features of disease, clinical characteristics, and associated outcomes.

TL;DR: In this paper, spatial transcriptomics and single-nuclear sequencing data sets were optimized to map 30 dominant cell types to a human nephrectomy, and the predicted cell-type spots corresponded with the underlying histopathology.

TL;DR: In this paper, a high-resolution cellular atlas of 100 cell types and states, their associated molecular profiles, and interactions within tissue neighborhoods was provided. But, the authors did not identify and define cellular states altered in kidney injury, encompassing cycling, adaptive or maladaptive repair, transitioning and degenerative states affecting several segments.

TL;DR: In this article, the myelotoxicity of cigarette smoking was delineated in a murine model, and human adipose-derived stem cells (hASC) was explored as a novel approach to mitigate this toxicity.

TL;DR: The gene expression signature of the human kidney interstitium is incompletely understood as mentioned in this paper, and the gene signatures were deconvolved using single nuclear RNA sequencing (snRNAseq) data derived from overlapping specimens.