M
Muhammad Saddiq Zahari
Researcher at Johns Hopkins University
Publications - 13
Citations - 2186
Muhammad Saddiq Zahari is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Breast cancer & Receptor tyrosine kinase. The author has an hindex of 10, co-authored 13 publications receiving 1912 citations. Previous affiliations of Muhammad Saddiq Zahari include University of California, San Francisco & Johns Hopkins University School of Medicine.
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Journal ArticleDOI
A draft map of the human proteome
Min-Sik Kim,Sneha M. Pinto,Derese Getnet,Raja Sekhar Nirujogi,Srikanth S. Manda,Raghothama Chaerkady,Anil K. Madugundu,Dhanashree S. Kelkar,Ruth Isserlin,Shobhit Jain,Joji Kurian Thomas,Babylakshmi Muthusamy,Pamela Leal-Rojas,Pamela Leal-Rojas,Praveen Kumar,Nandini A. Sahasrabuddhe,Lavanya Balakrishnan,Jayshree Advani,Bijesh George,Santosh Renuse,Lakshmi Dhevi N. Selvan,Arun H. Patil,Vishalakshi Nanjappa,Aneesha Radhakrishnan,Samarjeet Prasad,Tejaswini Subbannayya,Rajesh Raju,Manish Kumar,Sreelakshmi K. Sreenivasamurthy,Arivusudar Marimuthu,Gajanan Sathe,Sandip Chavan,Keshava K. Datta,Yashwanth Subbannayya,Apeksha Sahu,Soujanya D. Yelamanchi,Savita Jayaram,Pavithra Rajagopalan,Jyoti Sharma,Krishna R Murthy,Nazia Syed,Renu Goel,Aafaque Ahmad Khan,Sartaj Ahmad,Gourav Dey,Keshav Mudgal,Aditi Chatterjee,Tai-Chung Huang,Jun Zhong,Xinyan Wu,Patrick G. Shaw,Donald Freed,Muhammad Saddiq Zahari,Kanchan K Mukherjee,Subramanian Shankar,Anita Mahadevan,Henry H N Lam,Chris J. Mitchell,Susarla K. Shankar,Parthasarathy Satishchandra,John T. Schroeder,Ravi Sirdeshmukh,Anirban Maitra,Steven D. Leach,Charles G. Drake,Marc K. Halushka,T. S. Keshava Prasad,Ralph H. Hruban,Candace L. Kerr,Candace L. Kerr,Gary D. Bader,Christine A. Iacobuzio-Donahue,Harsha Gowda,Akhilesh Pandey +73 more
TL;DR: A draft map of the human proteome is presented using high-resolution Fourier-transform mass spectrometry to discover a number of novel protein-coding regions, which includes translated pseudogenes, non-c coding RNAs and upstream open reading frames.
Journal ArticleDOI
Activation of diverse signalling pathways by oncogenic PIK3CA mutations
Xinyan Wu,Santosh Renuse,Nandini A. Sahasrabuddhe,Muhammad Saddiq Zahari,Raghothama Chaerkady,Min-Sik Kim,Raja Sekhar Nirujogi,Morassa Mohseni,Praveen Kumar,Rajesh Raju,Jun Zhong,Jian Yang,Johnathan Neiswinger,Jun Seop Jeong,Robert H. Newman,Maureen A. Powers,B. L. Somani,Edward Gabrielson,Saraswati Sukumar,Vered Stearns,Jiang Qian,Heng Zhu,Bert Vogelstein,Ben Ho Park,Akhilesh Pandey +24 more
TL;DR: It is demonstrated that phosphorylation of cortactin by AKT1 is important for mutant PI3K enhanced cell migration and invasion through mutagenesis studies, and a quantitative and global approach is described for identifying mutation-specific signaling events and for discovering novel signaling molecules as readouts of pathway activation or potential therapeutic targets.
Journal ArticleDOI
Global phosphotyrosine survey in triple-negative breast cancer reveals activation of multiple tyrosine kinase signaling pathways
Xinyan Wu,Muhammad Saddiq Zahari,Binyun Ma,Ren Liu,Santosh Renuse,Nandini A. Sahasrabuddhe,Lily Chen,Raghothama Chaerkady,Min-Sik Kim,Jun Zhong,Christine A. Jelinek,Mustafa A. Barbhuiya,Pamela Leal-Rojas,Pamela Leal-Rojas,Yi Yang,Manoj Kumar Kashyap,Arivusudar Marimuthu,Min Ling,Mary Jo Fackler,Vanessa F. Merino,Zhen Zhang,Cynthia A. Zahnow,Edward Gabrielson,Vered Stearns,Juan Carlos Roa,Saraswati Sukumar,Parkash S. Gill,Akhilesh Pandey +27 more
TL;DR: The phosphotyrosine proteome analysis provided new insights into the heterogeneity in the activation status of tyrosine kinase pathways in TNBCs and presented an effective means of identifying important novel biomarkers and targets for therapy such as AXL in T NBC.
Journal ArticleDOI
The non-receptor tyrosine kinase TNK2/ACK1 is a novel therapeutic target in triple negative breast cancer
Xinyan Wu,Muhammad Saddiq Zahari,Santosh Renuse,Dhanashree S. Kelkar,Mustafa A. Bharbuiya,Pamela Leal Rojas,Vered Stearns,Edward Gabrielson,Pavani Malla,Saraswati Sukumar,Nupam P. Mahajan,Akhilesh Pandey +11 more
TL;DR: It is demonstrated that knockdown of TNK2 expression can substantially suppress the invasiveness and proliferation advantage of TNBC cells in vitro and tumor formation in xenograft mouse models, and this study suggests thatTNK2 is a novel potential therapeutic target for the treatment of T NBC.
Journal ArticleDOI
Phosphoproteomic Analysis Identifies Focal Adhesion Kinase 2 (FAK2) as a Potential Therapeutic Target for Tamoxifen Resistance in Breast Cancer
Xinyan Wu,Muhammad Saddiq Zahari,Santosh Renuse,Raja Sekhar Nirujogi,Min-Sik Kim,Srikanth S. Manda,Vered Stearns,Edward Gabrielson,Saraswati Sukumar,Akhilesh Pandey +9 more
TL;DR: Living analysis revealed that high expression of FAK2 is significantly associated with shorter metastasis-free survival in estrogen receptor-positive breast cancer patients treated with tamoxifen, and studies suggest that FAK 2 is a potential therapeutic target for the management of hormone-refractory breast cancers.