Nicola L. Harris

TL;DR: The results show that dietary fermentable fiber and SCFAs can shape the immunological environment in the lung and influence the severity of allergic inflammation.

TL;DR: The developing understanding of the far-reaching effects that the commensal flora have on mucosal and systemic immunity and their relevance to the effects of hygiene on human disease is described.

TL;DR: It is shown that neuromedin U (NMU) in mice is a fast and potent regulator of type 2 innate immunity in the context of a functional neuron–ILC2 unit, and this work reveals that neuron–ilC2 cell units confer immediate tissue protection through coordinated neuroimmune sensory responses.

TL;DR: The circumstances under which CD8+ T cells specific for pancreatic beta-islet antigens induce disease in mice expressing lymphocytic choriomeningitis virus as a transgene under the control of the rat insulin promoter are investigated to identify the 'inflammatory status' of the target organ as a separate and limiting factor determining the development of autoimmune disease.

TL;DR: In this paper, the authors used a model of allergic airway inflammation in GF mice to ascertain the relevance of commensal bacteria on the development of an allergic response, and found that the total number of infiltrating lymphocytes and eosinophils were elevated in the airways of allergic GF mice compared with control SPF mice.