N
Nicola Whiffin
Researcher at National Institutes of Health
Publications - 100
Citations - 10600
Nicola Whiffin is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Medicine & Gene. The author has an hindex of 32, co-authored 81 publications receiving 6241 citations. Previous affiliations of Nicola Whiffin include Broad Institute & Imperial College London.
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Journal ArticleDOI
Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1
Timothy H.T. Cheng,Deborah J. Thompson,Jodie N. Painter,Tracy A. O'Mara,Maggie Gorman,Lynn Martin,Claire Palles,Angela Jones,Daniel D. Buchanan,Aung Ko Win,John L. Hopper,Mark A. Jenkins,Noralane M. Lindor,Polly A. Newcomb,S. Gallinger,David V. Conti,Fred Schumacher,Graham Casey,Graham G. Giles,Graham G. Giles,Graham G. Giles,Paul D.P. Pharoah,Julian Peto,Angela Cox,Anthony J. Swerdlow,Fergus J. Couch,Julie M. Cunningham,Ellen L. Goode,Stacey J. Winham,Diether Lambrechts,Peter A. Fasching,Peter A. Fasching,Barbara Burwinkel,Barbara Burwinkel,Hermann Brenner,Hermann Brenner,Hiltrud Brauch,Hiltrud Brauch,Jenny Chang-Claude,Helga B. Salvesen,Vessela N. Kristensen,Hatef Darabi,Jingmei Li,Tao Liu,Annika Lindblom,Per Hall,Magdalena Echeverry De Polanco,Mónica Sans,Angel Carracedo,Sergi Castellví-Bel,Augusto Rojas-Martinez,Samuel Aguiar Jnr,Manuel R. Teixeira,Alison M. Dunning,Joe Dennis,Geoffrey Otton,Tony Proietto,Elizabeth G. Holliday,John Attia,Katie Ashton,Rodney J. Scott,Mark McEvoy,Sean C. Dowdy,Brooke L. Fridley,Henrica M.J. Werner,Jone Trovik,Tormund S. Njolstad,Emma Tham,Miriam Mints,Ingo B. Runnebaum,Peter Hillemanns,Thilo Dörk,Frédéric Amant,Stefanie Schrauwen,Alexander Hein,Matthias W. Beckmann,Arif B. Ekici,Kamila Czene,Alfons Meindl,Manjeet K. Bolla,Kyriaki Michailidou,Jonathan Tyrer,Qin Wang,Shahana Ahmed,Catherine S. Healey,Mitul Shah,Daniela Annibali,Jeroen Depreeuw,Nada Al-Tassan,Rebecca Harris,Brian F. Meyer,Nicola Whiffin,Fay J. Hosking,Ben Kinnersley,Susan M. Farrington,Maria Timofeeva,Albert Tenesa,Harry Campbell,Robert W. Haile,Shirley Hodgson,Luis G. Carvajal-Carmona,Jeremy Peter Cheadle,Douglas F. Easton,Malcolm G. Dunlop,Richard S. Houlston,Amanda B. Spurdle,Ian Tomlinson +106 more
TL;DR: Using CRC and EC genome-wide association series, it was found that the protective allele at one previously-identified CRC polymorphism was associated with EC risk, and neither of two previously-reported EC polymorphisms were associated with CRC risk.
Journal ArticleDOI
Spatiotemporal organization of Aurora-B by APC/CCdh1 after mitosis coordinates cell spreading through FHOD1.
Suzanne Floyd,Nicola Whiffin,Maria P. Gavilan,Stefan Kutscheidt,Maria De Luca,Chiara Marcozzi,Mingwei Min,Johnathan Watkins,Kathryn Chung,Oliver T. Fackler,Catherine Lindon +10 more
TL;DR: It is proposed that Cdh1 contributes to spatiotemporal organization of AurB activity and that organization of FHOD1 activity by AurB contributes to daughter cell spreading after mitosis.
Journal ArticleDOI
MLH1-93G > A is a risk factor for MSI colorectal cancer
Nicola Whiffin,Peter Broderick,Steven J. Lubbe,Alan M. Pittman,Steven Penegar,Ian Chandler,Richard S. Houlston +6 more
TL;DR: Data provide further evidence that MLH1-93G > A is a low-penetrance variant for CRC and support the proposition thatMLH 1-93 G > A acts as marker for a somatic event defining a specific CRC subtype.
Journal ArticleDOI
4258Re-evaluating the genetic contribution of monogenic dilated cardiomyopathy
Francesco Mazzarotto,Upasana Tayal,Rachel Buchan,William Midwinter,Alicja Wilk,Nicola Whiffin,H Watkins,B Funke,Declan P. O'Regan,I Olivotto,Paul J.R. Barton,S Prasad,Sarah Cook,J S Ware,Roddy Walsh +14 more
TL;DR: In the largest sequenced DCM cohort yet described, robust disease association is observed only with a limited number of genes, highlighting their importance in DCM and translating into high interpretability in diagnostic testing.
Journal ArticleDOI
Phenotypic Expression and Outcomes in Individuals With Rare Genetic Variants of Hypertrophic Cardiomyopathy
Antonio de Marvao,Kathryn A. McGurk,Sean L. Zheng,Marjola Thanaj,Wenjia Bai,Jinming Duan,Carlo Biffi,Francesco Mazzarotto,Ben Statton,Timothy J W Dawes,Nicoló Savioli,Brian P Halliday,Xiao Xu,Rachel Buchan,A. John Baksi,Marina Quinlan,Pawel Tokarczuk,Upasana Tayal,Catherine Francis,Nicola Whiffin,Pantazis I. Theotokis,Xiaolei Zhang,Mikyung Jang,Alaine Berry,Antonis Pantazis,Paul J.R. Barton,Daniel Rueckert,Sanjay K Prasad,Roddy Walsh,Carolyn Y. Ho,Stuart A. Cook,James S. Ware,Declan P. O'Regan +32 more
TL;DR: In this paper, the clinical significance of these variants in the general population was investigated. But little was known about the clinical importance of these variations in the case of HCC. But the authors did find that the variants in HCC is caused by rare variants in sarcomere-encoding genes, but little is known about their clinical significance.