Showing papers by "Paul Morris published in 2010"
University of Warwick1, Virginia Bioinformatics Institute2, University of East Anglia3, Utrecht University4, John Innes Centre5, Goethe University Frankfurt6, University of California, Riverside7, Virginia Tech8, University of California, Berkeley9, Lawrence Berkeley National Laboratory10, Washington University in St. Louis11, Agriculture and Agri-Food Canada12, Nanjing Agricultural University13, Centre national de la recherche scientifique14, University of Toulouse15, Wageningen University and Research Centre16, Wellcome Trust17, Broad Institute18, Bowling Green State University19
TL;DR: The genome sequence of the oomycete Hyaloperonospora arabidopsidis is reported, an obligate biotroph and natural pathogen of Arabidopsis thaliana, which exhibits dramatic reductions in genes encoding RXLR effectors, proteins associated with zoospore formation and motility, and enzymes for assimilation of inorganic nitrogen and sulfur.
Abstract: Many oomycete and fungal plant pathogens are obligate biotrophs, which extract nutrients only from living plant tissue and cannot grow apart from their hosts. Although these pathogens cause substantial crop losses, little is known about the molecular basis or evolution of obligate biotrophy. Here, we report the genome sequence of the oomycete Hyaloperonospora arabidopsidis (Hpa), an obligate biotroph and natural pathogen of Arabidopsis thaliana. In comparison with genomes of related, hemibiotrophic Phytophthora species, the Hpa genome exhibits dramatic reductions in genes encoding (i) RXLR effectors and other secreted pathogenicity proteins, (ii) enzymes for assimilation of inorganic nitrogen and sulfur, and (iii) proteins associated with zoospore formation and motility. These attributes comprise a genomic signature of evolution toward obligate biotrophy.
424 citations
Carleton University1, Agriculture and Agri-Food Canada2, Sainsbury Laboratory3, Michigan State University4, University of Utah5, Goethe University Frankfurt6, Colorado State University7, Newcastle University8, J. Craig Venter Institute9, University of Toulouse10, Scottish Association for Marine Science11, Wageningen University and Research Centre12, University of Aberdeen13, Broad Institute14, Mahidol University15, Bowling Green State University16, University of California, Riverside17, Virginia Tech18, University of Provence19, Agricultural Research Service20, SRI International21
TL;DR: Access to the P. ultimum genome has revealed not only core pathogenic mechanisms within the oomycetes but also lineage-specific genes associated with the alternative virulence and lifestyles found within the pythiaceous lineages compared to the Peronosporaceae.
Abstract: Background
Pythium ultimum is a ubiquitous oomycete plant pathogen responsible for a variety of diseases on a broad range of crop and ornamental species.
364 citations
TL;DR: In patients with coronary disease testosterone deficiency is common and impacts significantly negatively on survival, and prospective trials of testosterone replacement are needed to assess the effect of treatment on survival.
Abstract: Background To examine the effect of serum testosterone levels on survival in a consecutive series of men with confirmed coronary disease and calculate the prevalence of testosterone deficiency. Design Longitudinal follow-up study. Setting Tertiary referral cardiothoracic centre. Patients 930 consecutive men with coronary disease referred for diagnostic angiography recruited between June 2000 and June 2002 and followed up for a mean of 6.962.1 years. Outcome All-cause mortality and vascular mortality. Prevalence of testosterone deficiency. Results The overall prevalence of biochemical testosterone deficiency in the coronary disease cohort using bio-available testosterone (bio-T) <2.6 nmol/l was 20.9%, using total testosterone <8.1 nmol/l was 16.9% and using either was 24%. Excess mortality was noted in the androgen-deficient group compared with normal (41 (21%) vs 88 (12%), p¼0.002). The only parameters found to influence time to all-cause and vascular mortality (HR 6 95% CI) in multivariate analyses were the presence of left ventricular dysfunction (3.85; 1.72 to 8.33), aspirin therapy (0.63; 0.38 to 1.0), b-blocker therapy (0.45; 0.31 to 0.67) and low serum bio-T (2.27; 1.45 to 3.6). Conclusions In patients with coronary disease testosterone deficiency is common and impacts significantly negatively on survival. Prospective trials of testosterone replacement are needed to assess the effect of treatment on survival.
233 citations
TL;DR: In this paper, the authors examine judgment about the attempts of football players to deceptively exaggerate the effect of a tackle and provide a taxonomy of behaviors associated with deceptive and non-deceptive intentions.
Abstract: The three studies reported examine judgment about the attempts of footballers (soccer players) to deceptively exaggerate the effect of a tackle Study one reveals that non-professional participants agree about which players were attempting deception and those that were not; there was also agreement about the tackles in which the intentions were ambiguous Study two demonstrates that the intentions of tackled players match the judgment of their intentions by observers Study three provides a taxonomy of behaviors that are associated with deceptive and non deceptive intentions We conclude that deceptive intentions in this context are to a degree manifest in behavior and are observable
44 citations