E
Edgar Huitema
Researcher at University of Dundee
Publications - 52
Citations - 6137
Edgar Huitema is an academic researcher from University of Dundee. The author has contributed to research in topics: Effector & Oomycete. The author has an hindex of 28, co-authored 50 publications receiving 5571 citations. Previous affiliations of Edgar Huitema include Sainsbury Laboratory & Case Western Reserve University.
Papers
More filters
Journal ArticleDOI
Genome sequence and analysis of the Irish potato famine pathogen Phytophthora infestans.
Brian J. Haas,Sophien Kamoun,Sophien Kamoun,Michael C. Zody,Michael C. Zody,Rays H. Y. Jiang,Rays H. Y. Jiang,Robert E. Handsaker,Liliana M. Cano,Manfred Grabherr,Chinnappa D. Kodira,Chinnappa D. Kodira,Sylvain Raffaele,Trudy Torto-Alalibo,Trudy Torto-Alalibo,Tolga O. Bozkurt,Audrey M. V. Ah-Fong,Lucia Alvarado,Vicky L. Anderson,Miles R. Armstrong,Anna O. Avrova,Laura Baxter,Jim Beynon,Petra C. Boevink,Stephanie R. Bollmann,Jorunn I. B. Bos,Vincent Bulone,Guohong Cai,Cahid Cakir,James C. Carrington,Megan Chawner,Lucio Conti,Stefano Costanzo,Richard Ewan,Noah Fahlgren,Michael A. Fischbach,Johanna Fugelstad,Eleanor M. Gilroy,Sante Gnerre,Pamela J. Green,Laura J. Grenville-Briggs,John Griffith,Niklaus J. Grünwald,Karolyn Horn,Neil R. Horner,Chia-Hui Hu,Edgar Huitema,Dong-Hoon Jeong,Alexandra M. E. Jones,Jonathan D. G. Jones,Richard W. Jones,Elinor K. Karlsson,Sridhara G. Kunjeti,Kurt Lamour,Zhenyu Liu,Li-Jun Ma,Dan MacLean,Marcus C. Chibucos,Hayes McDonald,Jessica McWalters,Harold J. G. Meijer,William Morgan,Paul Morris,Carol A. Munro,Keith O'Neill,Keith O'Neill,Manuel D. Ospina-Giraldo,Andrés Pinzón,Leighton Pritchard,Bernard H Ramsahoye,Qinghu Ren,Silvia Restrepo,Sourav Roy,Ari Sadanandom,Alon Savidor,Sebastian Schornack,David C. Schwartz,Ulrike Schumann,Ben Schwessinger,Lauren Seyer,Ted Sharpe,Cristina Silvar,Jing Song,David J. Studholme,Sean M. Sykes,Marco Thines,Marco Thines,Peter J. I. van de Vondervoort,Vipaporn Phuntumart,Stephan Wawra,R. Weide,Joe Win,Carolyn A. Young,Shiguo Zhou,William E. Fry,Blake C. Meyers,Pieter van West,Jean B. Ristaino,Francine Govers,Paul R. J. Birch,Stephen C. Whisson,Howard S. Judelson,Chad Nusbaum +102 more
TL;DR: The sequence of the P. infestans genome is reported, which at ∼240 megabases (Mb) is by far the largest and most complex genome sequenced so far in the chromalveolates and probably plays a crucial part in the rapid adaptability of the pathogen to host plants and underpins its evolutionary potential.
Journal ArticleDOI
The C-terminal half of Phytophthora infestans RXLR effector AVR3a is sufficient to trigger R3a-mediated hypersensitivity and suppress INF1-induced cell death in Nicotiana benthamiana
Jorunn I. B. Bos,Thirumala-Devi Kanneganti,Carolyn A. Young,Cahid Cakir,Edgar Huitema,Joe Win,Miles R. Armstrong,Paul R. J. Birch,Sophien Kamoun +8 more
TL;DR: Structural-function experiments indicated that the 75-amino acid C-terminal half of AVR3aKI, which excludes the RXLR region, is sufficient for avirulence and suppression functions, consistent with the view that the N- terminal region of A VR3AKI and other RXLR effectors is involved in secretion and targeting but is not required for effector activity.
Journal ArticleDOI
EST Mining and Functional Expression Assays Identify Extracellular Effector Proteins From the Plant Pathogen Phytophthora
Trudy A. Torto,Shuang Li,Allison Styer,Edgar Huitema,Antonino Testa,Neil A. R. Gow,Pieter van West,Sophien Kamoun +7 more
TL;DR: The results indicate that combining data mining using PexFinder with PVX-based functional assays can facilitate the discovery of novel pathogen effector proteins and can be applied to a variety of eukaryotic plant pathogens, including oomycetes, fungi, and nematodes.
Journal ArticleDOI
Genome sequence of the necrotrophic plant pathogen Pythium ultimum reveals original pathogenicity mechanisms and effector repertoire
C. André Lévesque,C. André Lévesque,H. Brouwer,Liliana M. Cano,John P. Hamilton,Carson Holt,Edgar Huitema,Sylvain Raffaele,Gregg P. Robideau,Gregg P. Robideau,Marco Thines,Joe Win,Marcelo M. Zerillo,Gordon W. Beakes,Jeffrey L. Boore,Dana A. Busam,Bernard Dumas,Steve Ferriera,Susan I. Fuerstenberg,Claire M. M. Gachon,Elodie Gaulin,Francine Govers,Laura J. Grenville-Briggs,Neil R. Horner,Jessica B. Hostetler,Rays H. Y. Jiang,Justin Johnson,Theerapong Krajaejun,Haining Lin,Harold J. G. Meijer,Barry Moore,Paul Morris,Vipaporn Phuntmart,Daniela Puiu,Jyoti Shetty,Jason E. Stajich,Sucheta Tripathy,Stephan Wawra,Pieter van West,Brett R Whitty,Pedro M. Coutinho,Bernard Henrissat,Frank N. Martin,Paul Thomas,Brett M. Tyler,Ronald P. de Vries,Sophien Kamoun,Mark Yandell,Ned Tisserat,C. Robin Buell +49 more
TL;DR: Access to the P. ultimum genome has revealed not only core pathogenic mechanisms within the oomycetes but also lineage-specific genes associated with the alternative virulence and lifestyles found within the pythiaceous lineages compared to the Peronosporaceae.
Journal ArticleDOI
A Kazal-like extracellular serine protease inhibitor from Phytophthora infestans targets the tomato pathogenesis-related protease P69B.
TL;DR: Inhibition of tomato proteases by EPI1 could form a novel type of defense-counterdefense mechanism between plants and microbial pathogens, and points to a common virulence strategy between the oomycete plant pathogen P. infestans and several mammalian parasites, such as the apicomplexan Toxoplasma gondii.