P
Peter Wipf
Researcher at University of Pittsburgh
Publications - 795
Citations - 27717
Peter Wipf is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Total synthesis & Transmetalation. The author has an hindex of 83, co-authored 767 publications receiving 25316 citations. Previous affiliations of Peter Wipf include University of California, Los Angeles & University of Vermont.
Papers
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Journal ArticleDOI
Chiral Action at a Distance: Remote Substituent Effects on the Optical Activity of Calyculins A and B.
TL;DR: In this paper, a Boltzmann-averaged atomic contribution mapping (BAM) approach was proposed to analyze the long-range chiro-optical effect of the difference in optical rotations between two Calculus A and B. The polarizability characteristics of the CN substituent rather than perturbation of the stereogenic centers or the introduction of dissymmetry into the polyene chain give rise to the remarkable difference in rotation angles.
Journal ArticleDOI
Chemistry and Biology of Wortmannin
Peter Wipf,Robert J. Halter +1 more
TL;DR: Wortmannin is a potent enzyme inhibitor that binds to the ATP site of important regulatory kinases such as PI-3 kinase and Polo-like kinase as discussed by the authors.
Patent
Mitochondrially Targeted PARP Inhibitor, and Uses Thereof
TL;DR: In this paper, a mitochondrial-targeted PARP inhibitor is described, as well as methods of making and using the inhibitor, and methods of obtaining the PARP inhibitors are described.
Journal ArticleDOI
Carboalumination of 1-Alkynes and in situ Transmetalation to Higher Order Cyanocuprates. Stereospecific Synthesis of Tri- and Disubstituted Olefins by Conjugate Addition to Enones.
Robert E. Ireland,Peter Wipf +1 more
TL;DR: In this paper, a method for the selective cleavage of a benzodioxole (methylenedioxy group) to a methoxyphenol through the use of a p-methylthiophenoxide ion is described.
Patent
Method for separating organic compounds using fluorous separation systems
Dennis P. Curran,Rafael Ferritto,Ruah Sabine Hadida,Masahide Hashino,Patrick Jeger,Sun-Young Kim,Armido Studer,Peter Wipf +7 more
TL;DR: In this article, the authors present several methods of synthesis and separation in which organic/fluorous phase separation techniques are used to effect separations. And they also provide novel compositions of matter comprising fluorous Si, Sn and Ge compounds.