P
Peter Wipf
Researcher at University of Pittsburgh
Publications - 795
Citations - 27717
Peter Wipf is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Total synthesis & Transmetalation. The author has an hindex of 83, co-authored 767 publications receiving 25316 citations. Previous affiliations of Peter Wipf include University of California, Los Angeles & University of Vermont.
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Journal ArticleDOI
Optimization of Phenyl Indole Inhibitors of the AAA+ ATPase p97.
Matthew G. LaPorte,James C. Burnett,Raffaele Colombo,Stacie L. Bulfer,Celeste Alverez,Tsui-Fen Chou,R. Jeffrey Neitz,Neal Jeffrey Green,William J. Moore,Zhizhou Yue,Shan Li,Michelle R. Arkin,Peter Wipf,Donna M. Huryn +13 more
TL;DR: Optimization of the side-chain of a phenyl indole scaffold identified from a high-throughput screening campaign for inhibitors of the AAA+ ATPase p97 is reported, and the addition of an N-alkyl piperazine led to high potency and activity in cell-based assays.
Journal Article
Disruption of Insulin-Like Growth Factor-1 Signaling and Down-Regulation of Cdc2 by SC-ααδ9, a Novel Small Molecule Antisignaling Agent Identified in a Targeted Array Library
Andreas Vogt,Robert L. Rice,Catherine E. Settineri,Fumiaki Yokokawa,Shiho Yokokawa,Peter Wipf,John S. Lazo +6 more
TL;DR: The results suggest that overexpression of Cdc2 and increased dependence on insulin-like growth factor-1 autocrine stimulation are responsible for the increased sensitivity of simian virus 40 large T antigen mouse embryonic fibroblasts to SC-ααδ9.
Journal ArticleDOI
Synthesis and Ag(I) complexation studies of tethered westiellamide.
Peter Wipf,Chenbo Wang +1 more
TL;DR: NMR and fluorescence Ag(I) titrations confirmed that the tethered macrocycles preserve the unique, high-affinity coordination mode of westiellamide.
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The combination of thioxodihydroquinazolinones and platinum drugs reverses platinum resistance in tumor cells by inducing mitochondrial apoptosis independent of Bax and Bak
TL;DR: The thioxodihydroquinazolinone mdivi-1 is identified as a member of a novel class of small molecules that are able to induce Bax- and Bak-independent mitochondrial outer membrane permeabilization when combined with cisplatin, thereby efficiently triggering apoptosis in platinum-resistant tumor cells.
Journal ArticleDOI
Zirconocene-catalyzed cationic diels-alder reactions
Peter Wipf,Wenjing Xu +1 more
TL;DR: In situ prepared Cp2ZrCl⊕ catalyzes the formation of dioxolenium ions from α,β-unsaturated epoxy esters.