P
Peter Wipf
Researcher at University of Pittsburgh
Publications - 795
Citations - 27717
Peter Wipf is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Total synthesis & Transmetalation. The author has an hindex of 83, co-authored 767 publications receiving 25316 citations. Previous affiliations of Peter Wipf include University of California, Los Angeles & University of Vermont.
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Journal ArticleDOI
Solvent Effect on Optical Rotation: A Case Study of Methyloxirane in Water
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Studies on the synthesis of Stemona alkaloids; stereoselective preparation of the hydroindole ring system by oxidative cyclization of tyrosine
Peter Wipf,Yuntae Kim +1 more
TL;DR: The core hydroindole ring system of the Stemona alkaloids was prepared by oxidation of tyrosine with a hypervalent iodine reagent followed by a diastereotopic group-selective intramolecular conjugate addition.
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Thiolysis of oxazolines: A new, selective method for the direct conversion of peptide oxazolines into thiazolines
TL;DR: In this paper, a direct oxazoline→thiazoline conversion can be realized by thiolysis of oxazolines with H2S in methanol/triethylamine, followed by cyclodehydration with Burgess reagent.
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Structural Requirements for Optimized Delivery, Inhibition of Oxidative Stress, and Antiapoptotic Activity of Targeted Nitroxides
Jianfei Jiang,Igor V. Kurnikov,Natalia A. Belikova,Jingbo Xiao,Qing Zhao,Andrew A. Amoscato,Rebecca Braslau,Armido Studer,Mitchell P. Fink,Joel S. Greenberger,Peter Wipf,Valerian E. Kagan +11 more
TL;DR: Using a model of ActD-induced apoptosis in mouse embryonic cells, a library of nitroxides is screened to explore structure-activity relationships between their antioxidant/antiapoptotic properties and chemical composition and three-dimensional (3D) structure and it is established that the presence of the β-turn/β-sheet secondary structure is essential for the desired activity.
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Total synthesis and structure assignment of the antitumor antibiotic aranorosin
TL;DR: The structurally unique antifungal and antitumor antibiotic aranorosin was prepared in a convergent, stereoselective sequence and the corrected [α] D strongly indicated the (6'R)-stereochemistry for the natural compound.