Peter Wipf

TL;DR: The role of catalytic or stoichiometric quantities of H2O to organic and organometallic processes can lead to surprisingly beneficial effects on reaction rate, product yield, and regio-, diastereo, and enantioselectivity as mentioned in this paper.

TL;DR: The discovery of the first potent and selective cell-active small molecule inhibitor for PKD, benzoxoloazepinolone (CID755673), which inhibited the known biological actions of PKD1 including phorbol ester-induced class IIa histone deacetylase 5 nuclear exclusion, vesicular stomatitis virus glycoprotein transport from the Golgi to the plasma membrane, and the ilimaquinone-induced Golgi fragmentation.

TL;DR: The diisopropyl azodicarboxylate-triphenylphosphine mediated cyclization of serine and allo-threonine derivatives provides peptide oxazolines, whereas cyclisation of threonine containing substrates leads to N-acyl aziridines.