P
Peter Wipf
Researcher at University of Pittsburgh
Publications - 795
Citations - 27717
Peter Wipf is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Total synthesis & Transmetalation. The author has an hindex of 83, co-authored 767 publications receiving 25316 citations. Previous affiliations of Peter Wipf include University of California, Los Angeles & University of Vermont.
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Journal ArticleDOI
Determining absolute configuration in flexible molecules: a case study.
Kimberly Musa Specht,Joonwoo Nam,Douglas M. Ho,Nina Berova,Rama K. Kondru,David N. Beratan,Peter Wipf,Robert A. Pascal,Daniel Kahne +8 more
TL;DR: A combination of molecular modeling, solution NMR, and X-ray crystallography is used to illustrate why it is difficult to use solution methods alone for configuration assignment for conformationally flexible systems.
Journal ArticleDOI
Selective carbon–carbon bond formations with alkenylzirconocenes
Peter Wipf,Ruth L. Nunes +1 more
Journal ArticleDOI
Plasmodium falciparum encodes a single cytosolic type I Hsp40 that functionally interacts with Hsp70 and is upregulated by heat shock
Melissa Botha,Annette N. Chiang,Patrick G. Needham,Linda L. Stephens,Heinrich C. Hoppe,Simone Külzer,Jude M. Przyborski,Klaus Lingelbach,Peter Wipf,Jeffrey L. Brodsky,Addmore Shonhai,Gregory L. Blatch +11 more
TL;DR: Data presented here represent the first cellular and biochemical evidence for a PfHsp70–PfHsp40 partnership in the malaria parasite, and furthermore that the plasmodial and human Hsp70-–HSP40 chaperones possess unique attributes that are differentially modulated by small molecules.
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Chemical methodology as a source of small-molecule checkpoint inhibitors and heat shock protein 70 (Hsp70) modulators
Donna M. Huryn,Jeffrey L. Brodsky,Kay M. Brummond,Peter G. Chambers,Benjamin R. Eyer,Alex W. Ireland,Masaoki Kawasumi,Matthew G. LaPorte,Kayla R Lloyd,Baptiste Manteau,Paul Nghiem,Bettina Quade,Sandlin P. Seguin,Peter Wipf +13 more
TL;DR: In this paper, the authors describe the identification, characterization, and evolution of two small-molecule probes, which are used to selectively bind putative protein target(s) responsible for the observed activity.
Journal ArticleDOI
Titanocene(III)-catalyzed formation of indolines and azaindolines.
Peter Wipf,John P. Maciejewski +1 more
TL;DR: Reductive cyclization of epoxides tethered to substituted anilines and aminopyridines in the presence of titanocene dichloride and stoichiometric manganese metal promotes a radical annulation to form 3,3-disubstituted indolines and azaindolines.