Peter Wipf

TL;DR: A library of 94,491 compounds from the Molecular Library Screening Center Network was screened for the ability to inhibit interleukin-6 (IL-6)-induced pSTAT3 activation to identify selective inhibitors of STAT3 activation that would not inhibit STAT1 tumor suppressor functions.

TL;DR: The protected C(1) to C(15) segment of FK-506 has been prepared from D-glucose, glycolic and L-pipecolic acid as mentioned in this paper.

TL;DR: It is disclosed that a potent, selective, reversible, and noncompetitive PTP4A inhibitor, JMS-053, markedly enhanced microvascular barrier function after exposure of endothelial cells to vascular endothelial growth factor or lipopolysaccharide and demonstrated anticancer activity in a murine xenograft model of drug resistant human ovarian cancer.

TL;DR: Studies of organ specific radioprotection and in total body irradiation-induced hematopoietic syndrome in the mouse model for protection/mitigation facilitate rational means by which to move candidate small molecule drugs along the drug discovery pipeline into clinical development.

TL;DR: It is proposed that Fancd2–/– mice are a valuable radiosensitive animal model system, which can be used to evaluate potential radioprotective agents and biomarkers of both local oral cavity and distant marrow radiation toxicity were ameliorated by intraoral JP4-039/F15.