P
Peter Wipf
Researcher at University of Pittsburgh
Publications - 795
Citations - 27717
Peter Wipf is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Total synthesis & Transmetalation. The author has an hindex of 83, co-authored 767 publications receiving 25316 citations. Previous affiliations of Peter Wipf include University of California, Los Angeles & University of Vermont.
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Journal ArticleDOI
Is Cdc25 a Druggable Target
John S. Lazo,Peter Wipf +1 more
TL;DR: The rationale, approaches, progress and challenges for developing small molecule inhibitors of the Cdc25 family of activating phosphatases, implicated in cancer and Alzheimer's disease are reviewed.
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Silver(I)-Catalyzed Addition of Zirconocenes to Epoxy Esters: A New Entry to 1,4-Dicarbonyl Compounds and Pyridazinones
Peter Wipf,Joey-Lee Methot +1 more
TL;DR: In this article, the Ag(I)-catalyzed tandem epoxy ester rearrangement−dioxycarbenium ion addition reaction with alkenyl zirconocenes provides 1,4-keto esters that can be further converted to substituted pyridazinones.
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Kinetic vs. thermodynamic control in hydrozirconation reactions
TL;DR: In this article, a new method was proposed to prepare zirconocene hydrides in situ from readily available, air-stable ZIRconocene dihydride, which allowed the first time that kinetic hydrozirconation products of internal, non-functionalized alkenes can be formed in preference over isomerized, thermodynamic products.
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N-acetyl-L-cysteine protects astrocytes against proteotoxicity without recourse to glutathione
Amanda M. Gleixner,Daniel F. Hutchison,Sara Sannino,Tarun N. Bhatia,Lillian C. Leak,Patrick T. Flaherty,Peter Wipf,Jeffrey L. Brodsky,Rehana K. Leak +8 more
TL;DR: It is shown that NAC can protect astrocytes against protein misfolding stress (proteotoxicity), the hallmark of neurodegenerative disorders, and the findings suggest that the thiol group in NAC is required for its effects on glial viability and protein quality control.
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Total Synthesis and Biological Evaluation of Tubulysin Analogues.
Raffaele Colombo,Raffaele Colombo,Zhiyong Wang,Junyan Han,Raghavan Balachandran,Hikmat N. Daghestani,Daniel P. Camarco,Andreas Vogt,Billy W. Day,David Mendel,Peter Wipf +10 more
TL;DR: A second-generation synthesis of the exceedingly potent antimitotic agent N14-desacetoxytubulysin H is reported as well as the preparation of nine analogues of this lead structure and C-terminal modifications that preserve the exquisite biological activity of acid 1 are discovered.