P
Peter Wipf
Researcher at University of Pittsburgh
Publications - 795
Citations - 27717
Peter Wipf is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Total synthesis & Transmetalation. The author has an hindex of 83, co-authored 767 publications receiving 25316 citations. Previous affiliations of Peter Wipf include University of California, Los Angeles & University of Vermont.
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Journal ArticleDOI
Synthesis of a library of tricyclic azepinoisoindolinones.
TL;DR: The resulting library products provided selective hits among a large number of high-throughput screens reported in PubChem, thus illustrating the utility of the novel scaffold.
Journal Article
Small Molecule GS-Nitroxide Ameliorates Ionizing Irradiation-Induced Delay in Bone Wound Healing in a Novel Murine Model
Abhay S. Gokhale,Jean-Claude M. Rwigema,Michael W. Epperly,Julie Glowacki,Hong Wang,Peter Wipf,Julie P. Goff,Tracy Dixon,Ken Patrene,Joel S. Greenberger +9 more
TL;DR: A test system for radioprotection and mitigation by mitochondrial-targeted Tempol (GS-nitroxide, JP4-039) in a mouse injury/irradiation model of combined injury (fracture/IRradiation) should be useful for the development of new small molecule Radioprotectors.
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In vitro cytotoxicity, pharmacokinetics, tissue distribution, and metabolism of small-molecule protein kinase D inhibitors, kb-NB142-70 and kb-NB165-09, in mice bearing human cancer xenografts
Jianxia Guo,Dana M. Clausen,Jan H. Beumer,Robert A. Parise,Merrill J. Egorin,Karla Bravo-Altamirano,Peter Wipf,Elizabeth R. Sharlow,Qiming J. Wang,Julie L. Eiseman +9 more
TL;DR: In this article, the authors evaluated the in vitro cytotoxicity of two protein kinase D inhibitors, NB142-70 and its methoxy analogue, kb-NB165-09, and examined their in vivo efficacy and pharmacokinetics.
Journal ArticleDOI
Synthetic applications of ortho esters
TL;DR: In this article, the zirconocene-catalyzed rearrangement of epoxy esters to give 2,7,8-trioxabicy- clo(3.2) octanes (ABO-esters) adds a new modification to carboxylic acid chemistry.