다중혈관 관상동맥 환자에서 y-문합을 이용하여 양쪽 내흉동맥만을 사용한 우회술의 조기 성적

抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Examination of nature's favorite molecules reveals a striking preference for making carbon-heteroatom bonds over carbon-carbon bonds-surely no surprise given that carbon dioxide is nature's starting material and that most reactions are performed in water. Nucleic acids, proteins, and polysaccharides are condensation polymers of small subunits stitched together by carbon-heteroatom bonds. Even the 35 or so building blocks from which these crucial molecules are made each contain, at most, six contiguous C-C bonds, except for the three aromatic amino acids. Taking our cue from nature's approach, we address here the development of a set of powerful, highly reliable, and selective reactions for the rapid synthesis of useful new compounds and combinatorial libraries through heteroatom links (C-X-C), an approach we call "click chemistry". Click chemistry is at once defined, enabled, and constrained by a handful of nearly perfect "spring-loaded" reactions. The stringent criteria for a process to earn click chemistry status are described along with examples of the molecular frameworks that are easily made using this spartan, but powerful, synthetic strategy.

https://www.onlinelibrary.wiley.com/doi/pdf/10.1002/1521-3773%2820010601%2940%3A11%3C2004%3A%3AAID-ANIE2004%3E3.0.CO%3B2-5

Click Chemistry: Diverse Chemical Function from a Few Good Reactions.

https://pubs.rsc.org/en/content/articlepdf/2019/NP/C8NP00092A

Marine natural products.

CA : A Cancer Journal for Clinicians

Oxidative cyclization of bis-hydroxynaphthyl ethers allows concise total syntheses of palmarumycin CP 1 and deoxypreussomerin A in 8-9 steps and 15–35% overall yield from 5-hydroxy-8-methoxy-1-tetralone ( 8 ). Polymer-bound triphenyl phosphine was found to be a superior reagent for the rapid preparation of a small library of palmarumycin analogs. Preliminary biological evaluation of naphthoquinone spiroketals against MCF-7 and MDA-MB-231 human breast cancer cells revealed several low-micromolar growth inhibitors.

Synthesis and Biological Evaluation of Deoxypreussomerin A and Palmarumycin CP1 and Related Naphthoquinone Spiroketals.

2-Trimethylsilylethanesulfonyl chloride (SES-Cl) 



intermediate: sodium β-trimethylsilylethanesulfonate




product: 2-Trimethylsilylethylsulfonyl chloride (2)





Keywords:

addition, to CC;
replacement reactions, hydroxy by halogen;
sulfonation, C-sulfonation

2‐Trimethylsilylethanesulfonyl Chloride (SES‐Cl)

Optical Activity: From Structure-Function to Structure Prediction

The present invention relates to a pharmaceutical composition, particularly to a pharmaceutical composition for use in the treatment and/or prevention of immune-mediated diseases which are characterized by a Th1 environment such as autoimmune diseases, wherein said pharmaceutical composition comprises a compound of formula (I) as defined herein. The present invention also relates to the use of a compound according to formula (I) as defined herein for activating the production of at least one Th2 polarizing cytokine in NKT cells.

Peter Wipf

Papers

Synthesis and Biological Evaluation of Deoxypreussomerin A and Palmarumycin CP1 and Related Naphthoquinone Spiroketals.

2‐Trimethylsilylethanesulfonyl Chloride (SES‐Cl)

Optical Activity: From Structure-Function to Structure Prediction

Novel th2 polarizing compounds

Formal Total Synthesis of (+)‐Diepoxin σ.