Peter Wipf

TL;DR: In this article, the multi-component condensation of organozirconocene, aldimine and zinc carbenoid was applied to the stereoselective synthesis of cyclopropane amino acid derivatives.

TL;DR: A ligand fragment and residue preference mapping algorithm to map the profiles of the interactions between these fragments and the 20 proteinogenic amino acid residues and demonstrated that the fragment-residue interaction profiles generated from the PDB ligand fragments can be used to detect whether these fragments are in their favorable or unfavorable environments.

TL;DR: The C(1) to N(14) segment of the potent thrombin inhibitor cyclotheonamide A was prepared from L-arginine, L-proline, and L-asparagine.

TL;DR: It is found that disorazole C1 enhanced the mitotic index and chromatin condensation and arrested cells in the G2/M phase of the cell cycle and hypothesized that this biological activity may be mediated by microtubule perturbation.

TL;DR: The design and application of a reporter cell line is described that makes use of the phenomenon of transcriptional synergy to amplify the detection of changes in splicing, such that a three- to five-fold change in Splicing pattern is observed as a 30- to 50-foldchange in GFP expression.