P
Peter Wipf
Researcher at University of Pittsburgh
Publications - 795
Citations - 27717
Peter Wipf is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Total synthesis & Transmetalation. The author has an hindex of 83, co-authored 767 publications receiving 25316 citations. Previous affiliations of Peter Wipf include University of California, Los Angeles & University of Vermont.
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NAD(P)H:Quinone Oxidoreductase-1-Dependent and -Independent Cytotoxicity of Potent Quinone Cdc25 Phosphatase Inhibitors.
TL;DR: NQO1 detoxified Cpd 5, probably by reducing it to a less active hydroquinone, whereas NSC 95397- and NSC 663284-generated cytotoxicity was unaffected by NQO2, indicating similar Cdc25 inhibition.
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Synthesis and biological evaluation of caulibugulones A–E
TL;DR: The marine bryozoan metabolites caulibugulone A-E were prepared from a readily available isoquinoline dione and found to be potent and selective inhibitors of the dual specificity phosphatase Cdc25B.
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Zirconocene-catalyzed epoxy ester - ortho ester rearrangement: A new method for the protection of polyfunctionalized carboxylic acids and the asymmetric synthesis of ortho esters
TL;DR: In situ prepared Cp2(Cl)Zr catalyzes the formation of ortho eśters from epoxy esters as discussed by the authors, and acid-sensitive α-amino and α-hydroxy acid derivatives are converted in high yield to 2,7,8-trioxabicyclo[3.2.1] octanes (ABO-esters) using this protocol.
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Synthetic applications of organozirconocenes
TL;DR: In this paper, a transmetalation scheme for carbon-zirconium bond formation was developed for selective alkylation reactions with organic electrophiles, and the resulting functional group tolerance of organozirconocenes is useful for the preparation of the organometallic species.
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Combinatorial chemistry and contemporary pharmacology.
John S. Lazo,Peter Wipf +1 more
TL;DR: Cell-based assays that use optical endpoints permit investigation of a wide variety of functional properties of these compounds including specific intracellular biochemical pathways, protein-protein interactions, and the subcellular localization of targets.