Regina Stoeber

TL;DR: An in vitro/in silico method was established that predicts the risk of human DILI in relation to oral doses and blood concentrations of test compounds to the probability of hepatotoxicity and application to the rat hepatotoxicant pulegone resulted in an ADI similar to values previously established based on animal experiments.

TL;DR: To quantitatively describe disturbed development on a genome-wide basis, the concept based on the indices Dp and Di offers the possibility to quantitatively express the propensity of test compounds to interfere with normal development.

TL;DR: The median cytotoxicity of the test compounds increased between 1 and 2 days of incubation, with no or only a minimal further increase until day 7, and it remains to be studied whether the different results obtained for some individual compounds after longer exposure periods would correspond better to human-repeated dose toxicity.

TL;DR: The study shows that despite the intratumoral heterogeneity the analysis of only one or few replicates per tumor can be justified, when large cohorts of patients have to be analyzed.

TL;DR: It is reported that downregulation of WDR5 by shRNA in breast cancer cells antagonizes the epithelial-to-mesenchymal transition through re-differentiation and reduces metastasis in a mouse model, and that targeting the WDR 5-TGFβ axis by a small molecular inhibitor reduces the migratory potential of breast cancers cells.