L
Leon van Aerts
Publications - 3
Citations - 120
Leon van Aerts is an academic researcher. The author has contributed to research in topics: Cmax & Poison control. The author has an hindex of 2, co-authored 3 publications receiving 66 citations.
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Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations
Wiebke Albrecht,Franziska Kappenberg,Tim Brecklinghaus,Regina Stoeber,Rosemarie Marchan,Mian Zhang,Kristina E Ebbert,Hendrik Kirschner,Marianna Grinberg,Marianna Grinberg,Marcel Leist,Wolfgang Moritz,Cristina Cadenas,Ahmed Ghallab,Ahmed Ghallab,Jörg Reinders,Nachiket Vartak,Christoph van Thriel,Klaus Golka,Laia Tolosa,José V. Castell,Georg Damm,Georg Damm,Daniel Seehofer,Daniel Seehofer,Alfonso Lampen,Albert Braeuning,Thorsten Buhrke,Anne Cathrin Behr,Axel Oberemm,Xiaolong Gu,Naim Kittana,Bob van de Water,Reinhard Kreiling,Susann Fayyaz,Leon van Aerts,Bård Smedsrød,Heidrun Ellinger-Ziegelbauer,Thomas Steger-Hartmann,Ursula Gundert-Remy,Anja Zeigerer,Anett Ullrich,Dieter Runge,Serene M. L. Lee,Tobias S. Schiergens,Lars Kuepfer,Alejandro Aguayo-Orozco,Agapios Sachinidis,Karolina Edlund,Iain Gardner,Jörg Rahnenführer,Jan G. Hengstler +51 more
TL;DR: An in vitro/in silico method was established that predicts the risk of human DILI in relation to oral doses and blood concentrations of test compounds to the probability of hepatotoxicity and application to the rat hepatotoxicant pulegone resulted in an ADI similar to values previously established based on animal experiments.
Journal ArticleDOI
Finding synergies for 3Rs - Toxicokinetics and read-across: Report from an EPAA partners' Forum
Charles Laroche,M. Aggarwal,Hans Bender,Paul Benndorf,Barbara Birk,Jonathan Crozier,Gianni Dal Negro,Federica De Gaetano,Christian Desaintes,Iain Gardner,Bruno Hubesch,A. Irizar,David John,Vikas Kumar,Alfonso Lostia,Irene Manou,Mario Monshouwer,Boris P. Müller,Alicia Paini,Kirsty Reid,Timothy Rowan,Magdalini Sachana,Katrin Schutte,Catrina Stirling,Rob Taalman,Leon van Aerts,Renate Weissenhorn,Ursula G. Sauer +27 more
TL;DR: A Partners' Forum Toxicokinetics and Read‐Across was convened to provide an overview on research activities to develop in vitro toxicokinetics methods and physiologically‐based kinetic (PBK) models and to find synergies to enhance use of toxicokinetic data to strengthen read‐across.
Journal ArticleDOI
NAM-supported read-across: From case studies to regulatory guidance in safety assessment.
Costanza Rovida,Sylvia Escher,Matthias Herzler,Susanne Hougaard Bennekou,Hennicke Kamp,Dinant Kroese,Lidka Maslankiewicz,Martijn J Moné,Grace Patlewicz,Nisha S. Sipes,Leon van Aerts,Andrew White,Takashi Yamada,Bob van de Water +13 more
TL;DR: The use of new approach methodologies (NAMs) in support of read-across (RAx) approaches for regulatory purposes is a main goal of the EU-ToxRisk project as discussed by the authors.