K
Klaus Golka
Researcher at Technical University of Dortmund
Publications - 229
Citations - 6615
Klaus Golka is an academic researcher from Technical University of Dortmund. The author has contributed to research in topics: Bladder cancer & Population. The author has an hindex of 39, co-authored 211 publications receiving 6066 citations. Previous affiliations of Klaus Golka include University of Karachi.
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Journal ArticleDOI
A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci
Nathaniel Rothman,Montserrat Garcia-Closas,Nilanjan Chatterjee,Núria Malats,Xifeng Wu,Jonine D. Figueroa,Francisco X. Real,David Van Den Berg,Giuseppe Matullo,Dalsu Baris,Michael J. Thun,Lambertus A. Kiemeney,Paolo Vineis,Immaculata De Vivo,Demetrius Albanes,Mark P. Purdue,Thorunn Rafnar,Michelle A.T. Hildebrandt,Anne E. Kiltie,Olivier Cussenot,Klaus Golka,Rajesh Kumar,Jack A. Taylor,Jose I. Mayordomo,Kevin B. Jacobs,Manolis Kogevinas,Amy Hutchinson,Zhaoming Wang,Yi-Ping Fu,Ludmila Prokunina-Olsson,Laurie Burdett,Meredith Yeager,William Wheeler,Adonina Tardón,Consol Serra,Alfredo Carrato,Reina García-Closas,Josep Lloreta,Alison Johnson,Molly Schwenn,Margaret R. Karagas,Alan R. Schned,Gerald L. Andriole,Robert L. Grubb,Amanda Black,Eric J. Jacobs,W. Ryan Diver,Susan M. Gapstur,Stephanie J. Weinstein,Jarmo Virtamo,Victoria K. Cortessis,Manuela Gago-Dominguez,Malcolm C. Pike,Malcolm C. Pike,Mariana C. Stern,Jian-Min Yuan,David J. Hunter,Monica McGrath,Colin P.N. Dinney,Bogdan Czerniak,Meng Chen,Hushan Yang,Sita H. Vermeulen,Katja K.H. Aben,J. Alfred Witjes,Remco R. R. Makkinje,Patrick Sulem,Søren Besenbacher,Kari Stefansson,Kari Stefansson,Elio Riboli,Paul Brennan,Salvatore Panico,Carmen Navarro,Naomi E. Allen,H. Bas Bueno-de-Mesquita,Dimitrios Trichopoulos,Dimitrios Trichopoulos,Neil E. Caporaso,Maria Teresa Landi,Federico Canzian,Börje Ljungberg,Anne Tjønneland,Françoise Clavel-Chapelon,D T Bishop,Mark Teo,Margaret A. Knowles,Simonetta Guarrera,Silvia Polidoro,Fulvio Ricceri,Carlotta Sacerdote,Alessandra Allione,Geraldine Cancel-Tassin,Silvia Selinski,Jan G. Hengstler,Holger Dietrich,Tony Fletcher,Peter Rudnai,Eugen Gurzau,Kvetoslava Koppova,Sophia C.E. Bolick,Ashley C. Godfrey,Zongli Xu,José I Sanz-Velez,Maria D. Garcia-Prats,Manuel Sanchez,Gabriel Valdivia,Stefano Porru,Simone Benhamou,Simone Benhamou,Robert N. Hoover,Joseph F. Fraumeni,Debra T. Silverman,Stephen J. Chanock +113 more
TL;DR: Two new regions associated with bladder cancer on chromosomes 22q13.1, 19q12 and 2q37.1 are identified and previous candidate associations for the GSTM1 deletion and a tag SNP for NAT2 acetylation status are validated, and interactions with smoking in both regions are found.
Journal ArticleDOI
Sequence Variant on 8q24 Confers Susceptibility to Urinary Bladder Cancer
Lambertus A. Kiemeney,Steinunn Thorlacius,Patrick Sulem,Frank Geller,Katja K H Aben,Simon N. Stacey,Julius Gudmundsson,Margret Jakobsdottir,Jon Thor Bergthorsson,Asgeir Sigurdsson,Thorarinn Blondal,J. Alfred Witjes,Sita H. Vermeulen,Christina A. Hulsbergen-van de Kaa,Dorine W. Swinkels,Martine Ploeg,Erik B. Cornel,Henk Vergunst,Thorgeir E. Thorgeirsson,Daniel F. Gudbjartsson,Sigurjon A. Gudjonsson,Gudmar Thorleifsson,Kari T. Kristinsson,Magali Mouy,Steinunn Snorradottir,Donatella Placidi,Marcello Campagna,Cecilia Arici,Kvetoslava Koppova,Eugene Gurzau,Peter Rudnai,Eliane Kellen,Silvia Polidoro,Simonetta Guarrera,Carlotta Sacerdote,Manuel Sanchez,Berta Saez,Gabriel Valdivia,Charlotta Ryk,Petra J. de Verdier,Annika Lindblom,Klaus Golka,D. Timothy Bishop,Margaret A. Knowles,Sigfus Nikulasson,Vigdis Petursdottir,Eirikur Jonsson,Gudmundur Geirsson,Baldvin Kristjansson,Jose I. Mayordomo,Gunnar Steineck,Stefano Porru,Frank Buntinx,Frank Buntinx,Maurice P. Zeegers,Maurice P. Zeegers,Tony Fletcher,Rajesh Kumar,Giuseppe Matullo,Paolo Vineis,Anne E. Kiltie,Jeffrey R. Gulcher,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Augustine Kong,Thorunn Rafnar,Kari Stefansson,Kari Stefansson +67 more
TL;DR: No association was observed between UBC and the four 8q24 variants previously associated with prostate, colorectal and breast cancers, nor did rs9642880 associate with any of these three cancers.
Journal ArticleDOI
Carcinogenicity of azo colorants: influence of solubility and bioavailability.
TL;DR: It appears well established that the aromatic amine components from azo pigments based on 3,3'-dichlorobenzidine are practically not bioavailable, and it is very unlikely that occupational exposure to insoluble azo Pigments would be associated with a substantial risk of (bladder) cancer in man.
Journal ArticleDOI
A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer.
Lambertus A. Kiemeney,Patrick Sulem,Søren Besenbacher,Sita H. Vermeulen,Asgeir Sigurdsson,Gudmar Thorleifsson,Daniel F. Gudbjartsson,Simon N. Stacey,Julius Gudmundsson,Carlo Zanon,Jelena Kostic,Gisli Masson,Hjordis Bjarnason,Stefan T Palsson,Oskar B Skarphedinsson,Sigurjon A. Gudjonsson,J. Alfred Witjes,Anne J. Grotenhuis,Gerald W. Verhaegh,D. Timothy Bishop,Sei C. Sak,Ananya Choudhury,Faye Elliott,Jennifer H. Barrett,Carolyn D. Hurst,Petra J. de Verdier,Charlotta Ryk,Peter Rudnai,Eugene Gurzau,Kvetoslava Koppova,Paolo Vineis,Paolo Vineis,Silvia Polidoro,Silvia Polidoro,Simonetta Guarrera,Simonetta Guarrera,Carlotta Sacerdote,Marcello Campagna,Donatella Placidi,Cecilia Arici,Maurice P. Zeegers,Maurice P. Zeegers,Eliane Kellen,Berta Saez Gutierrez,José I Sanz-Velez,Manuel Sanchez-Zalabardo,Gabriel Valdivia,Maria D. Garcia-Prats,Jan G. Hengstler,Meinolf Blaszkewicz,Holger Dietrich,Roel A. Ophoff,Roel A. Ophoff,Leonard H. van den Berg,Kristin Alexiusdottir,Kristleifur Kristjansson,Gudmundur Geirsson,Sigfus Nikulasson,Vigdis Petursdottir,Augustine Kong,Thorgeir E. Thorgeirsson,N. Aydin Mungan,Annika Lindblom,Michael A. van Es,Stefano Porru,Frank Buntinx,Frank Buntinx,Klaus Golka,Jose I. Mayordomo,Rajesh Kumar,Giuseppe Matullo,Giuseppe Matullo,Gunnar Steineck,Gunnar Steineck,Anne E. Kiltie,Katja K H Aben,Eirikur Jonsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Margaret A. Knowles,Thorunn Rafnar,Kari Stefansson,Kari Stefansson +82 more
TL;DR: The results show a link between germline variants, somatic mutations of FGFR3 and risk of UBC, and Notably, rs798766[T] shows stronger association with low-grade and low-stage UBC than with more aggressive forms of the disease and is associated with higher risk of recurrence in low- grade stage Ta tumors.
Journal ArticleDOI
Markers of genetic susceptibility in human environmental hygiene and toxicology: The role of selected CYP, NAT and GST genes
Ricarda Thier,Thomas Brüning,Peter H. Roos,Hans-Peter Rihs,Klaus Golka,Yon Ko,Hermann M. Bolt +6 more
TL;DR: The hypothesis has been put forward that genetic polymorphism of GSTM1 might be linked with the occurrence of human bladder cancer, and this supports the hypothesis that exposure to PAH might causally be involved in urothelial cancers.