Serene M. L. Lee

TL;DR: An in vitro/in silico method was established that predicts the risk of human DILI in relation to oral doses and blood concentrations of test compounds to the probability of hepatotoxicity and application to the rat hepatotoxicant pulegone resulted in an ADI similar to values previously established based on animal experiments.

TL;DR: This method presents a modified version of a two-step collagenase perfusion procedure to isolate hepatocytes as described by Seglen (1), which results in a large yield of hepatocytes with a viability of 77±10%.

TL;DR: Hepatocellular carcinoma patient data showed the increased expression of several HDACs in HCC tissues compared to non-tumorous liver and there was a strong correlation in the expression of HDAC class IIa (HDAC4, 5, 7, 9) as well as HDAC2 and 8 (class I) and HDAC10 (class IIb) andHDAC11 (class IV) in H CC tissues of individual patients, which might indicate a common mechanism

TL;DR: It was showed that at the longest time-point at RT, the RNA quality decreased significantly by 20%.

TL;DR: Bile acids significantly modulate metabolic and drug associated gene networks that are connected to distinct shifts in the microRNAome, giving novel insights on how BA enfold metabolic and system toxic effects.