R
Regina Stoeber
Researcher at Technical University of Dortmund
Publications - 6
Citations - 172
Regina Stoeber is an academic researcher from Technical University of Dortmund. The author has contributed to research in topics: Breast cancer & Incubation period. The author has an hindex of 4, co-authored 6 publications receiving 128 citations.
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Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations
Wiebke Albrecht,Franziska Kappenberg,Tim Brecklinghaus,Regina Stoeber,Rosemarie Marchan,Mian Zhang,Kristina E Ebbert,Hendrik Kirschner,Marianna Grinberg,Marianna Grinberg,Marcel Leist,Wolfgang Moritz,Cristina Cadenas,Ahmed Ghallab,Ahmed Ghallab,Jörg Reinders,Nachiket Vartak,Christoph van Thriel,Klaus Golka,Laia Tolosa,José V. Castell,Georg Damm,Georg Damm,Daniel Seehofer,Daniel Seehofer,Alfonso Lampen,Albert Braeuning,Thorsten Buhrke,Anne Cathrin Behr,Axel Oberemm,Xiaolong Gu,Naim Kittana,Bob van de Water,Reinhard Kreiling,Susann Fayyaz,Leon van Aerts,Bård Smedsrød,Heidrun Ellinger-Ziegelbauer,Thomas Steger-Hartmann,Ursula Gundert-Remy,Anja Zeigerer,Anett Ullrich,Dieter Runge,Serene M. L. Lee,Tobias S. Schiergens,Lars Kuepfer,Alejandro Aguayo-Orozco,Agapios Sachinidis,Karolina Edlund,Iain Gardner,Jörg Rahnenführer,Jan G. Hengstler +51 more
TL;DR: An in vitro/in silico method was established that predicts the risk of human DILI in relation to oral doses and blood concentrations of test compounds to the probability of hepatotoxicity and application to the rat hepatotoxicant pulegone resulted in an ADI similar to values previously established based on animal experiments.
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Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Tox ukn and STOP-Tox ukk tests
Vaibhav Shinde,Lisa Hoelting,Sureshkumar Perumal Srinivasan,Johannes Meisig,Johannes Meisig,Kesavan Meganathan,Smita Jagtap,Marianna Grinberg,Julia Liebing,Nils Bluethgen,Nils Bluethgen,Jörg Rahnenführer,Eugen Rempel,Regina Stoeber,Stefan Schildknecht,Sunniva Förster,Patricio Godoy,Christoph van Thriel,John Antonydas Gaspar,Jürgen Hescheler,Tanja Waldmann,Jan G. Hengstler,Marcel Leist,Agapios Sachinidis +23 more
TL;DR: To quantitatively describe disturbed development on a genome-wide basis, the concept based on the indices Dp and Di offers the possibility to quantitatively express the propensity of test compounds to interfere with normal development.
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Relevance of the incubation period in cytotoxicity testing with primary human hepatocytes.
Xiaolong Gu,Xiaolong Gu,Wiebke Albrecht,Karolina Edlund,Franziska Kappenberg,Jörg Rahnenführer,Marcel Leist,Wolfgang Moritz,Patricio Godoy,Cristina Cadenas,Rosemarie Marchan,Tim Brecklinghaus,Laia Tolosa Pardo,José V. Castell,Iain Gardner,Bo Han,Jan G. Hengstler,Regina Stoeber +17 more
TL;DR: The median cytotoxicity of the test compounds increased between 1 and 2 days of incubation, with no or only a minimal further increase until day 7, and it remains to be studied whether the different results obtained for some individual compounds after longer exposure periods would correspond better to human-repeated dose toxicity.
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Highlight report: Intratumoral metabolomic heterogeneity of breast cancer.
TL;DR: The study shows that despite the intratumoral heterogeneity the analysis of only one or few replicates per tumor can be justified, when large cohorts of patients have to be analyzed.
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Role of WDR5 in breast cancer prognosis.
TL;DR: It is reported that downregulation of WDR5 by shRNA in breast cancer cells antagonizes the epithelial-to-mesenchymal transition through re-differentiation and reduces metastasis in a mouse model, and that targeting the WDR 5-TGFβ axis by a small molecular inhibitor reduces the migratory potential of breast cancers cells.