R
Robert J. Lefkowitz
Researcher at Howard Hughes Medical Institute
Publications - 867
Citations - 153371
Robert J. Lefkowitz is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Receptor & G protein-coupled receptor. The author has an hindex of 214, co-authored 860 publications receiving 147995 citations. Previous affiliations of Robert J. Lefkowitz include University of Nice Sophia Antipolis & University of Stuttgart.
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Introduction to Special Section on β-Arrestins
TL;DR: The signaling capacities of these versatile adapter molecules are reviewed and the possible implications for cellular processes such as chemotaxis and apoptosis are discussed.
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The genomic clone G-21 which resembles a β-adrenergic receptor sequence encodes the 5-HT 1A receptor
Annick Fargin,John R. Raymond,Martin J. Lohse,Brian K. Kobilka,Marc G. Caron,Robert J. Lefkowitz +5 more
TL;DR: The protein product of the genomic clone, G21, transiently expressed in monkey kidney cells has all the typical ligand-binding characteristics of the 5-hydroxytryptamine (5-HT1A) receptor.
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GRKs and β-arrestins: roles in receptor silencing, trafficking and signaling
TL;DR: G-protein-coupled receptor kinases and β-arrestins are involved in an increasing number of interactions with non-receptor proteins, broadening the variety of their cellular functions.
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Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation.
TL;DR: This set of mutated receptors exhibits a graded range of elevated biological activities, apparently representing a spectrum of receptor conformations which mimic the "active" state of the wild type receptor.