R
Robert J. Lefkowitz
Researcher at Howard Hughes Medical Institute
Publications - 867
Citations - 153371
Robert J. Lefkowitz is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Receptor & G protein-coupled receptor. The author has an hindex of 214, co-authored 860 publications receiving 147995 citations. Previous affiliations of Robert J. Lefkowitz include University of Nice Sophia Antipolis & University of Stuttgart.
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Journal ArticleDOI
A crystal clear view of the beta2-adrenergic receptor.
TL;DR: The crystal structure of a second G protein–coupled receptor sheds light on these key pharmaceutical targets.
Journal ArticleDOI
G protein signaling and vein graft intimal hyperplasia: Reduction of intimal hyperplasia in vein grafts by a G(βγ) inhibitor suggests a major role of G protein signaling in lesion development
Mark G. Davies,Tam T. Huynh,Gregory J. Fulton,Robert J. Lefkowitz,Einar Svendsen,Per Otto Hagen,Walter J. Koch +6 more
TL;DR: In this paper, the carboxyl terminus of the β-adrenergic receptor kinase (βARKCT) contains a Gβγ-binding domain, which was found to play a major role in vein graft intimal hyperplasia.
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Inhibition of Spontaneous β2-Adrenergic Activation Rescues β1-Adrenergic Contractile Response in Cardiomyocytes Overexpressing β2-Adrenoceptor
Sheng Jun Zhang,Heping Cheng,Ying Ying Zhou,Ding Ji Wang,Weizhong Zhu,Bruce D. Ziman,Harold Spurgoen,Robert J. Lefkowitz,Edward G. Lakatta,Walter J. Koch,Rui-Ping Xiao +10 more
TL;DR: It is concluded that constitutive β2-AR activation induces a heterologous desensitization of β1-ARs independent of βARK1 and Giproteins; suppression of the constitutive α1-adrenergic receptor kinase activity reduces the base-line cAMP and contractility and restores the diminished β 1-AR contractile response.
Journal ArticleDOI
Enhanced vasorelaxation by overexpression of beta 2-adrenergic receptors in large arteries.
Mohamed A. Gaballa,Karsten Peppel,Robert J. Lefkowitz,Maria L. Aguirre,Paul C. Dolber,Gregory D. Pennock,Walter J. Koch,Steven Goldman +7 more
TL;DR: Adenoviral-mediated delivery of beta 2-ARs into large artery walls results in enhanced beta-AR-mediated vasorelaxation via augmentation in cAMP levels in vascular smooth muscle cells.