R
Robert J. Lefkowitz
Researcher at Howard Hughes Medical Institute
Publications - 867
Citations - 153371
Robert J. Lefkowitz is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Receptor & G protein-coupled receptor. The author has an hindex of 214, co-authored 860 publications receiving 147995 citations. Previous affiliations of Robert J. Lefkowitz include University of Nice Sophia Antipolis & University of Stuttgart.
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Journal ArticleDOI
Specificity of the functional interactions of the beta-adrenergic receptor and rhodopsin with guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles.
R A Cerione,C Staniszewski,J. L. Benovic,Robert J. Lefkowitz,M G Caron,Peter Gierschik,Robert L. Somers,Allen M. Spiegel,Juan Codina,Lutz Birnbaumer +9 more
TL;DR: The functional interactions of two pure receptor proteins with three different pure guanine nucleotide regulatory proteins in phosphatidylcholine vesicles suggest that the different nucleotide regulators are capable of a common upper limit of catalytic efficiency which can best be attained when coupled to the appropriate receptor.
Journal ArticleDOI
The mammalian beta 2-adrenergic receptor: purification and characterization.
TL;DR: Peptide mapping and lectin binding studies of the hamster, guinea pig, and rat lung beta 2-adrenergic receptors reveal significant similarities suggestive of evolutionary homology.
Journal ArticleDOI
The G-protein-coupled receptor kinases beta ARK1 and beta ARK2 are widely distributed at synapses in rat brain.
Jeffrey L. Arriza,Ted M. Dawson,Richard B. Simerly,Lee J. Martin,Marc G. Caron,Solomon H. Snyder,Robert J. Lefkowitz +6 more
TL;DR: Beta ARK-mediated receptor desensitization may reflect a general molecular mechanism operative on many G-protein-coupled receptor systems and, particularly, synaptic neurotransmitter receptors.
Book ChapterDOI
Mechanisms of beta-adrenergic receptor desensitization and resensitization.
TL;DR: The phosphatases and regulatory mechanisms involved in this resensitization process have only recently begun to be elucidated and are included in this chapter.
Journal ArticleDOI
Mutagenesis of the beta 2-adrenergic receptor: how structure elucidates function.
TL;DR: The cloning of .B2AR cDNA from hamster, human, rat, and mouse, as well as the gene from human genomic DNA, has allowed us to study the signal transduction pathway initiated by the f32AR and mediated by Gs.