R
Robert J. Lefkowitz
Researcher at Howard Hughes Medical Institute
Publications - 867
Citations - 153371
Robert J. Lefkowitz is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Receptor & G protein-coupled receptor. The author has an hindex of 214, co-authored 860 publications receiving 147995 citations. Previous affiliations of Robert J. Lefkowitz include University of Nice Sophia Antipolis & University of Stuttgart.
Papers
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Journal ArticleDOI
Functionally active targeting domain of the beta-adrenergic receptor kinase: an inhibitor of G beta gamma-mediated stimulation of type II adenylyl cyclase
James Inglese,Louis M. Luttrell,J A Iñiguez-Lluhi,Kazushige Touhara,Walter J. Koch,Robert J. Lefkowitz +5 more
TL;DR: The data suggest that this His6 fusion protein derived from the carboxyl terminus of beta ARK1 provides a specific probe for defining G beta gamma-mediated processes and for studying the structural features of a G beta Gamma-binding domain.
Journal ArticleDOI
The beta-adrenergic receptor: rapid purification and covalent labeling by photoaffinity crosslinking.
Robert G. L. Shorr,Sarah L. Heald,Peter W. Jeffs,T N Lavin,Mark W. Strohsacker,Robert J. Lefkowitz,Marc G. Caron +6 more
TL;DR: The photoaffinity crosslinking approach may be useful for labeling a variety of small molecule and neurotransmitter receptors when appropriate ligands can be synthesized.
Book ChapterDOI
β-Adrenergic Receptor-Coupled Adenylate Cyclase
TL;DR: β-Adrenergic receptor-coupled adenylate cyclase is regulated by both amplification and desensitization processes, suggesting that covalent modification (phosphorylation) may represent a general mechanism for regulating receptor function.
Journal ArticleDOI
G-protein-coupled receptors: regulatory role of receptor kinases and arrestin proteins.
Robert J. Lefkowitz,James Inglese,Walter J. Koch,Julie A. Pitcher,H Attramadal,Marc G. Caron +5 more
Journal ArticleDOI
Determination of the G beta gamma-binding domain of phosducin. A regulatable modulator of G beta gamma signaling.
TL;DR: It is demonstrated that the amino terminus of phosducin, a 33-kDa G beta gamma-binding retinal phosphoprotein, contains sequences homologous with the G beta Gamma-binding domain of beta ARK, and the binding of G Beta gamma to phos Ducin can be regulated by PKA-phosphorylation in an intact cell model system.