R
Robert J. Lefkowitz
Researcher at Howard Hughes Medical Institute
Publications - 867
Citations - 153371
Robert J. Lefkowitz is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Receptor & G protein-coupled receptor. The author has an hindex of 214, co-authored 860 publications receiving 147995 citations. Previous affiliations of Robert J. Lefkowitz include University of Nice Sophia Antipolis & University of Stuttgart.
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Receptor regulation: beta-arrestin moves up a notch.
TL;DR: β-arrestin, a protein known to regulate the signalling, trafficking and degradation of mammalian seven-transmembrane-spanning receptors, has now been identified as a regulator of ubiquitination and degrading of the Notch receptor in Drosophila melanogaster.
Journal ArticleDOI
Synthetic nanobodies as angiotensin receptor blockers.
Conor McMahon,Dean P. Staus,Laura M. Wingler,Laura M. Wingler,Jialu Wang,Meredith A. Skiba,Matthias Elgeti,Wayne L. Hubbell,Howard A. Rockman,Andrew C. Kruse,Robert J. Lefkowitz,Robert J. Lefkowitz +11 more
TL;DR: A selection methodology to enrich for functionally modulatory antibodies using a yeast-displayed library of synthetic camelid antibody fragments called “nanobodies” is described, and multiple nanobodies are discovered that act as antagonists of the angiotensin II type 1 receptor (AT1R).
Journal Article
Identification of the ligand-binding subunit of the human 5-hydroxytryptamine1A receptor with N-(p-azido-m-[125I] iodophenethyl)spiperone, a high affinity radioiodinated photoaffinity probe.
John R. Raymond,A. Fargin,Martin J. Lohse,John W. Regan,Susan E. Senogles,Robert J. Lefkowitz,Marc G. Caron +6 more
TL;DR: The availability of the high specific activity, high affinity, photoaffinity ligand [125I]N3-NAPS and of a potent immunoprecipitating antiserum (JWR21) should greatly facilitate the biochemical characterization of the human 5-HT1A receptor.
Journal Article
Homologous desensitization of the beta-adrenergic receptor. Functional integrity of the desensitized receptor from mammalian lung.
TL;DR: Heterologous desensitization may involve a local sequestration of a functionally intact beta-adrenergic receptor away from the effector adenylate cyclase effector system as assessed by the formation of RH in agonist competition curves.