R
Robert J. Lefkowitz
Researcher at Howard Hughes Medical Institute
Publications - 867
Citations - 153371
Robert J. Lefkowitz is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Receptor & G protein-coupled receptor. The author has an hindex of 214, co-authored 860 publications receiving 147995 citations. Previous affiliations of Robert J. Lefkowitz include University of Nice Sophia Antipolis & University of Stuttgart.
Papers
More filters
Journal ArticleDOI
Defective lymphocyte chemotaxis in β-arrestin2- and GRK6-deficient mice
Alan M. Fong,Richard T. Premont,Ricardo M. Richardson,Yen-Rei A. Yu,Robert J. Lefkowitz,Dhavalkumar D. Patel +5 more
TL;DR: Results indicate that β-arrestin2 and GRK6 actually play positive regulatory roles in mediating the chemotactic responses of T and B lymphocytes to CXCL12.
Journal ArticleDOI
Regulation of β-Adrenergic Receptor Signaling by S-Nitrosylation of G-Protein-Coupled Receptor Kinase 2
Erin J. Whalen,Matthew W. Foster,Akio Matsumoto,Kentaro Ozawa,Jonathan D. Violin,Loretta G. Que,Christopher D. Nelson,Moran Benhar,Janelle R. Keys,Howard A. Rockman,Walter J. Koch,Yehia Daaka,Robert J. Lefkowitz,Robert J. Lefkowitz,Jonathan S. Stamler +14 more
TL;DR: It is shown in mice that SNOs increase beta- AR expression and prevent agonist-stimulated receptor downregulation; and in cells, SNOs decrease GRK2-mediated beta-AR phosphorylation and subsequent recruitment of beta-arrestin to the receptor, resulting in the attenuation of receptor desensitization and internalization.
Journal ArticleDOI
β-Arrestin-Mediated Localization of Smoothened to the Primary Cilium
Jeffrey J. Kovacs,Erin J. Whalen,Renshui Liu,Kunhong Xiao,Jihee Kim,Minyong Chen,Jiangbo Wang,Wei Chen,Robert J. Lefkowitz +8 more
TL;DR: It is demonstrated that β-arrestins mediate the activity-dependent interaction of Smo and the kinesin motor protein Kif3A and suggested roles for β-Arrestins in mediating the intracellular transport of a 7TMR to its obligate subcellular location for signaling.
Journal ArticleDOI
Structure of the adrenergic and related receptors.
TL;DR: The isolation and sequencing of a number of G protein-coupled receptors has now provided extensive primary structure information for this family of homologous proteins, suggesting that the family of proteins may grow to include receptors for many neurotransmitters and perhaps many peptide hormones.
Journal ArticleDOI
ACTH Receptors in the Adrenal: Specific Binding of ACTH-125I and Its Relation to Adenyl Cyclase
TL;DR: This study demonstrates directly the binding of ACTH to its biologically significant site in direct proportion to their biological activity.